Title:
CYCLO(PROLYL-GLYCINE) AND METHODS OF USE TO TREAT NEURAL DISORDERS
Document Type and Number:
WIPO Patent Application WO2003039487
Kind Code:
A3
Abstract:
Embodiments of pharmaceutical compositions comprising cyclo(Pro-Gly) and methods for use in treating neural degeneration are provided. Cyclic PG substantially prevents toxic neural degeneration and cell death, and promotes neurite outgrowth in neurons, especially cerebellar neurons. The neuroprotective and neurorenenerative effects of cPG are useful to treat behavioural neurological deficits involving motor control pathways.
Inventors:
GUAN JIAN (NZ)
GLUCKMAN PETER DAVID (NZ)
SIEG FRANK (NZ)
GLUCKMAN PETER DAVID (NZ)
SIEG FRANK (NZ)
Application Number:
PCT/US2002/036235
Publication Date:
January 15, 2004
Filing Date:
November 12, 2002
Export Citation:
Assignee:
NEURONZ LTD (NZ)
NEURONZ BIOSCIENCES INC (US)
GUAN JIAN (NZ)
GLUCKMAN PETER DAVID (NZ)
SIEG FRANK (NZ)
NEURONZ BIOSCIENCES INC (US)
GUAN JIAN (NZ)
GLUCKMAN PETER DAVID (NZ)
SIEG FRANK (NZ)
International Classes:
A61K38/12; A61K38/18; A61K38/19; A61K38/27; A61K38/30; (IPC1-7): A61K38/00; A61K31/495
Domestic Patent References:
| WO2000013650A2 | 2000-03-16 |
Other References:
GUDASHEVA ET AL.: "Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain", FEBS LETTERS, vol. 391, 1996, pages 149 - 152, XP002970720
DATABASE CA [online] OSTROVSKAYA ET AL.: "GVS-111, novel dipeptide cognition enhancer", XP002970721, accession no. STN Database accession no. 1998:597878
DATABASE CA [online] OSTROVSKAYA ET AL.: "GVS-111, novel dipeptide cognition enhancer", XP002970721, accession no. STN Database accession no. 1998:597878
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