Title:
CYCLOTHIOUREA COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/133846
Kind Code:
A1
Abstract:
The present invention relates to a cyclothiourea compound and the use thereof. In particular, disclosed in the present invention are a compound having the structure as shown in formula (A) which can be used as an HBV replication inhibitor or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt, a hydrate or a solvate thereof. The present invention also relates to a pharmaceutical composition comprising the compound and the use thereof in treating hepatitis B.
Inventors:
WANG ZHE (CN)
WANG XIAOGUANG (CN)
FAN GUOQIN (CN)
LU CENBIN (CN)
YANG SAI (CN)
WANG XIAOGUANG (CN)
FAN GUOQIN (CN)
LU CENBIN (CN)
YANG SAI (CN)
Application Number:
PCT/CN2018/073460
Publication Date:
July 26, 2018
Filing Date:
January 19, 2018
Export Citation:
Assignee:
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07D417/04; A61K31/4025; A61K31/4155; A61K31/422; A61K31/549; A61K31/554; A61P31/20; A61P35/00; C07D207/34; C07D417/14
Domestic Patent References:
| WO2018011163A1 | 2018-01-18 | |||
| WO2015132276A1 | 2015-09-11 |
Other References:
LEIS, SIMON ET AL.: "ReFlexIn: A Flexible Receptor Protein-Ligand Docking Scheme Evaluated on HIV-1 Protease", PLOS ONE, vol. 7, no. 10, 24 October 2012 (2012-10-24), pages e48008, XP055506038
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
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