Title:
CYSTATIN RNA COMPOSITIONS FOR TISSUE ENGINEERING
Document Type and Number:
WIPO Patent Application WO/2023/130022
Kind Code:
A3
Abstract:
A composition comprising, for example, chemically modified RNA (cmRNA) encoding CST6 or a polypeptide with at least 80% amino acid sequence identity thereto, and methods of making and using the cmRNA, are provided.
Inventors:
PHRUTTIWANICHAKUN PORNPOJ (US)
SALEM ALIASGER K (US)
SALEM ALIASGER K (US)
Application Number:
PCT/US2022/082553
Publication Date:
August 10, 2023
Filing Date:
December 29, 2022
Export Citation:
Assignee:
UNIV IOWA RES FOUND (US)
PHRUTTIWANICHAKUN PORNPOJ (US)
PHRUTTIWANICHAKUN PORNPOJ (US)
International Classes:
A61K38/57; A61P19/08; A61P19/10; C12N15/88
Domestic Patent References:
| WO2019222277A1 | 2019-11-21 | |||
| WO2014152940A1 | 2014-09-25 |
Foreign References:
| US20160220698A1 | 2016-08-04 | |||
| US5985601A | 1999-11-16 |
Other References:
SONG J ET AL: "The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 340, no. 1, 3 February 2006 (2006-02-03), pages 175 - 182, XP024924027, ISSN: 0006-291X, [retrieved on 20060203], DOI: 10.1016/J.BBRC.2005.11.171
BRIGGS JON J ET AL: "Cystatin E/M suppresses legumain activity and invasion of human melanoma", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 15 January 2010 (2010-01-15), pages 17, XP021066895, ISSN: 1471-2407, DOI: 10.1186/1471-2407-10-17
ZOHREH SADAT BADIEYAN ET AL: "Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering", STEM CELLS TRANSLATIONAL MEDICINE, 19 March 2019 (2019-03-19), US, XP055736504, ISSN: 2157-6564, DOI: 10.1002/sctm.18-0259
BRIGGS JON J ET AL: "Cystatin E/M suppresses legumain activity and invasion of human melanoma", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 1, 15 January 2010 (2010-01-15), pages 17, XP021066895, ISSN: 1471-2407, DOI: 10.1186/1471-2407-10-17
ZOHREH SADAT BADIEYAN ET AL: "Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering", STEM CELLS TRANSLATIONAL MEDICINE, 19 March 2019 (2019-03-19), US, XP055736504, ISSN: 2157-6564, DOI: 10.1002/sctm.18-0259
Attorney, Agent or Firm:
PERDOK, Monique M. et al. (US)
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