CYSTEINE PROTEASE INHIBITORS

Title:

CYSTEINE PROTEASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2002076939

Kind Code:

A3

Abstract:

Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present invention can be identified by their mode of action in disrupting the ability of cysteine proteases and, in particular, caspases to cleave a peptide chain. These compounds are useful in inhibiting cysteine protease or cysteine protease-like proteins and for treating infections diseases or physiopathological diseases or disorders attributed to the presence of excessive or insufficient levels of cysteine proteases.

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Inventors:

ARAD DORIT (US)
BOLLON ARTHUR P (US)
YOUNG DAVID G (US)
PEEK ANDREW S (US)
POLAND BRADLEY W (US)
SHAW BAILIN (US)
VALLURUPALLI JYOTHI (US)

Application Number:

PCT/US2002/003785

Publication Date:

October 16, 2003

Filing Date:

February 05, 2002

Export Citation:

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Assignee:

EXEGENICS INC (US)
ARAD DORIT (US)
BOLLON ARTHUR P (US)
YOUNG DAVID G (US)
PEEK ANDREW S (US)
POLAND BRADLEY W (US)
SHAW BAILIN (US)
VALLURUPALLI JYOTHI (US)

International Classes:

A61P9/10; A61P17/14; A61P19/02; A61P21/04; A61P25/28; A61P35/00; A61P37/06; C07C49/86; C07C50/32; C07C50/38; C07C225/30; C07C233/31; C07C233/76; C07C251/20; C07C251/24; C07C251/48; C07C251/86; C07C271/12; C07C271/28; C07C271/64; C07C309/44; C07C317/24; C07C323/22; C07D211/90; C07D213/53; C07D213/90; C07D215/233; C07D215/24; C07D215/50; C07D221/14; C07D223/16; C07D239/56; C07D241/44; C07D263/57; C07D307/54; C07D307/88; C07D333/38; C07D417/04; C07D471/04; C07F15/02; C07D215/22; C07D263/56; (IPC1-7): C07D211/00; A61K31/12; A61K31/13; A61K31/135; A61K31/15; A61K31/16; A61K31/165; A61K31/19; A61K31/195; A61K31/21; A61K31/27; A61K31/335; A61K31/35; A61K31/40; A61K31/415; A61K31/44; A61K31/445; A61K31/50; C07C50/00; C07D213/00; C07D231/00; C07D237/00; C07D295/00; C07D303/00; C07D311/00

Domestic Patent References:

WO1997003940A1

1997-02-06

Foreign References:

JPS62221685A	1987-09-29
GB841927A	1960-07-20

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