Title:
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MODULATORS FOR TREATING AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/237174
Kind Code:
A3
Abstract:
Described are methods of treating cystic kidney disease. Also disclosed are methods of reducing the size and/or number of cysts in autosomal dominant polycystic kidney disease.
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Inventors:
CEBOTARU LIUDMILA (US)
GUGGINO WILLIAM B (US)
GUGGINO WILLIAM B (US)
Application Number:
PCT/US2018/038806
Publication Date:
February 28, 2019
Filing Date:
June 21, 2018
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
International Classes:
A61K31/44; A61K31/427; A61K31/517; A61P13/12
Foreign References:
| US20160038475A1 | 2016-02-11 |
Other References:
LOPES-PSCHECO ET AL.: "CFTR modulators: shedding light on precision medicine for cystic fibrosis", FRONTIERS IN PHARMACOLOGY, vol. 7, no. 275, 2016, pages 1 - 20, XP055579664
KIM, SOO WAN: "Pathogenesis and new treatment of autosomal doninant polycystic kidney disease", THE KOREAN JOURNAL OF NEPHROLOGY, vol. 30, 2011, pages 231 - 238, XP055660408
MORALES, MARCELO M. ET AL.: "The cystic fibrosis transmembrane regulator (CFTR) in the kidney", ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, vol. 72, no. 3, 2000, pages 399 - 406, XP055579665
ANTIGNY, FABRICE ET AL.: "CFTR and Ca2+ signaling in cystic fibrosis", FRONTIERS IN PHARMACOLOGY, vol. 2, 2011, pages 1 - 8, XP055579667
YANDA, MURALI K. ET AL.: "A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 293, no. 29, 6 June 2018 (2018-06-06), pages 11513 - 11526, XP055579671
KIM, SOO WAN: "Pathogenesis and new treatment of autosomal doninant polycystic kidney disease", THE KOREAN JOURNAL OF NEPHROLOGY, vol. 30, 2011, pages 231 - 238, XP055660408
MORALES, MARCELO M. ET AL.: "The cystic fibrosis transmembrane regulator (CFTR) in the kidney", ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, vol. 72, no. 3, 2000, pages 399 - 406, XP055579665
ANTIGNY, FABRICE ET AL.: "CFTR and Ca2+ signaling in cystic fibrosis", FRONTIERS IN PHARMACOLOGY, vol. 2, 2011, pages 1 - 8, XP055579667
YANDA, MURALI K. ET AL.: "A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 293, no. 29, 6 June 2018 (2018-06-06), pages 11513 - 11526, XP055579671
Attorney, Agent or Firm:
CHILDERS, Jeffrey W. (US)
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