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Title:
CYTOCHROME P450 MONOOXYGENASE DECOY SUBSTRATE
Document Type and Number:
WIPO Patent Application WO/2019/049991
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a simpler and more efficient hydroxyhydrocarbon production technique using a cytochrome P450 monooxygenase decoy substrate, and provides: a cytochrome P450 monooxygenase decoy substrate which includes a compound represented by general formula (1) and can be used for the production of a hydroxyhydrocarbon in a cell; and a method for producing a hydroxyhydrocarbon in a cell using the cytochrome P450 monooxygenase decoy substrate.

Inventors:
WATANABE, Yoshihito (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
SHOJI, Osami (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
Application Number:
JP2018/033217
Publication Date:
March 14, 2019
Filing Date:
September 07, 2018
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (1 Furo-cho, Chikusa-ku Nagoya-sh, Aichi 01, 〒4648601, JP)
International Classes:
C07K5/078; C12P1/00; C12P7/02; C12N15/53
Domestic Patent References:
WO2017061624A12017-04-13
Other References:
SHOJI, 0. ET AL.: "Direct hydroxylation of benzene to phenol by cytochrome P450BM3 triggered by amino acid derivatives", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 56, 2017, pages 10324 - 10329, XP055581498
SUZUKI, K. ET AL.: "Control of stereoselectivity of benzylie hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules,", CATALYSIS SCIENCE & TECHNOLOGY, vol. 7, no. 15, 7 August 2017 (2017-08-07), pages 3332 - 3338, XP055581501
CHOWDHARY, P. K. ET AL.: "Bacillus megaterium CYP102A1 oxidation of acy 1 homoserine lactones and acyl homoserines", BIOCHEMISTRY, vol. 46, no. 50, 2007, pages 14429 - 14437, XP055581503
KARASAWA, M. ET AL.: "Whole-cell biotransformation of benzene to phenol catalysed by intracellular cytochrome P450BM3 activated by external additives", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, no. 38, 2018, pages 12264 - 12269, XP055581550
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (Kitahama TNK Building, 1-7-1 Doshomachi, Chuo-ku, Osaka-sh, Osaka 45, 〒5410045, JP)
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