Title:
CYTOKINE SIGNAL REGULATORS
Document Type and Number:
WIPO Patent Application WO2000028034
Kind Code:
A3
Abstract:
The invention provides human cytokine signal regulators (CKSR) and polynucleotides which identify and encode CKSR. The invention provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CKSR.
More Like This:
Inventors:
YUE HENRY (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
Application Number:
PCT/US1999/026811
Publication Date:
November 09, 2000
Filing Date:
November 10, 1999
Export Citation:
Assignee:
INCYTE PHARMA INC (US)
YUE HENRY (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
YUE HENRY (US)
CORLEY NEIL C (US)
GUEGLER KARL J (US)
BAUGHN MARIAH R (US)
International Classes:
G01N33/50; A61K38/00; A61K45/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): C12N15/12; A61K38/17; C07K14/47; C07K16/18; C12N1/21; C12Q1/68
Domestic Patent References:
| WO1997048723A2 | 1997-12-24 |
Other References:
NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "np33f08.s1 NCI-CGAP-Lu1 Homo sapiens cDNA clone IMAGE:1118151 3' similar to TR:G915311 G915311 ABL INTERACTOR 2.", EMBL DATABASE ENTRY AA622957, ACESSION NUMBER AA622957, 16 October 1997 (1997-10-16), XP002136504
KHARITONENKOV A ET AL: "A FAMILY OF PROTEINS THAT INHIBIT SIGNALLING THROUGH TYROSINE KINASE RECEPTORS", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 386, 13 March 1997 (1997-03-13), pages 181 - 186, XP002064043, ISSN: 0028-0836
D. ZIEMNICKA-KOTULA ET AL: "Identification of a candidate human spectrin Src homology 3 Domain-nbinding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 22, 29 May 1998 (1998-05-29), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 13681 - 13692, XP002136505, ISSN: 0021-9258
A YOSHIMURA ET AL: "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to Tyrosine-phosphorylated interleukin-3 and erythropoietin", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 14, no. 12, 1 January 1995 (1995-01-01), pages 2816 - 2826, XP002088456, ISSN: 0261-4189
R STARR ET AL: "A family of cytokine-inducible inhibitors of signalling", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 387, 26 June 1997 (1997-06-26), pages 917 - 921, XP002085491, ISSN: 0028-0836
KHARITONENKOV A ET AL: "A FAMILY OF PROTEINS THAT INHIBIT SIGNALLING THROUGH TYROSINE KINASE RECEPTORS", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 386, 13 March 1997 (1997-03-13), pages 181 - 186, XP002064043, ISSN: 0028-0836
D. ZIEMNICKA-KOTULA ET AL: "Identification of a candidate human spectrin Src homology 3 Domain-nbinding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 273, no. 22, 29 May 1998 (1998-05-29), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, pages 13681 - 13692, XP002136505, ISSN: 0021-9258
A YOSHIMURA ET AL: "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to Tyrosine-phosphorylated interleukin-3 and erythropoietin", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 14, no. 12, 1 January 1995 (1995-01-01), pages 2816 - 2826, XP002088456, ISSN: 0261-4189
R STARR ET AL: "A family of cytokine-inducible inhibitors of signalling", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 387, 26 June 1997 (1997-06-26), pages 917 - 921, XP002085491, ISSN: 0028-0836
Download PDF:
Previous Patent: NUCLEIC ACIDS AND POLYPEPTIDES HAVING ALTERED EXPRESSION IN THE T84 GUT BARRIER MODEL
Next Patent: CHEMOKINE $g(b)-7
Next Patent: CHEMOKINE $g(b)-7