Title:
CYTOKINE STORM INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/239068
Kind Code:
A1
Abstract:
The present invention relates to a novel cytokine storm inhibitor containing, as an active ingredient, a compound represented by general formula [1]: [in the formula, R1 R2, R3, R4, R5, and X are as defined in the description], or a pharmacologically acceptable salt thereof.
Inventors:
OTANI YUTA (JP)
HONDA AYUMI (JP)
HONDA AYUMI (JP)
Application Number:
PCT/JP2021/017721
Publication Date:
November 17, 2022
Filing Date:
May 10, 2021
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
A61K31/497; A61P37/06; A61P43/00
Domestic Patent References:
| WO2019065793A1 | 2019-04-04 |
Other References:
KURAMOTO KAZUYA; KODAMA AYUMI; HOMAN JUNKO; NAKAYA YOHEI; KITAMURA TOSHIO; NAITO HARUNA: "Dual Inhibition of the STAT3 and Src Pathways by NS-018, a JAK2 and Src-Family Kinase Inhibitor, Reduces Myeloma Cell Proliferation and Adhesion and Suppresses Osteoclast Formation", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 118, no. 21, 18 November 2011 (2011-11-18), US , pages 2900, XP086625506, ISSN: 0006-4971, DOI: 10.1182/blood.V118.21.2900.2900
KODAMA, A. ET AL.: "P-257: Ns-018 suppresses myeloma cell proliferation and osteolysis by inhibiting JAK2 and SRC signaling. ", CLINICAL LYMPHOMA MYELOMA AND LEUKEMIA, vol. 13, no. 1, 31 January 2013 (2013-01-31), NL , pages S167 - S168, XP009541272, ISSN: 2152-2650
HONDA AYUMI, KURAMOTO KAZUYA, NIWA TOMOKO, NAITO HARUNA: "NS-018 reduces myeloma cell proliferation and suppresses osteolysis through inhibition of the JAK2 and Src signaling pathways", BLOOD CANCER JOURNAL, vol. 8, no. 7, 1 July 2018 (2018-07-01), pages 62, XP093007556, DOI: 10.1038/s41408-018-0098-z
HOJYO SHINTARO, UCHIDA MONA, TANAKA KUMIKO, HASEBE RIE, TANAKA YUKI, MURAKAMI MASAAKI, HIRANO TOSHIO: "How COVID-19 induces cytokine storm with high mortality", INFLAMMATION AND REGENERATION, vol. 40, no. 1, 1 December 2020 (2020-12-01), XP093007563, DOI: 10.1186/s41232-020-00146-3
KODAMA, A. ET AL.: "P-257: Ns-018 suppresses myeloma cell proliferation and osteolysis by inhibiting JAK2 and SRC signaling. ", CLINICAL LYMPHOMA MYELOMA AND LEUKEMIA, vol. 13, no. 1, 31 January 2013 (2013-01-31), NL , pages S167 - S168, XP009541272, ISSN: 2152-2650
HONDA AYUMI, KURAMOTO KAZUYA, NIWA TOMOKO, NAITO HARUNA: "NS-018 reduces myeloma cell proliferation and suppresses osteolysis through inhibition of the JAK2 and Src signaling pathways", BLOOD CANCER JOURNAL, vol. 8, no. 7, 1 July 2018 (2018-07-01), pages 62, XP093007556, DOI: 10.1038/s41408-018-0098-z
HOJYO SHINTARO, UCHIDA MONA, TANAKA KUMIKO, HASEBE RIE, TANAKA YUKI, MURAKAMI MASAAKI, HIRANO TOSHIO: "How COVID-19 induces cytokine storm with high mortality", INFLAMMATION AND REGENERATION, vol. 40, no. 1, 1 December 2020 (2020-12-01), XP093007563, DOI: 10.1186/s41232-020-00146-3
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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