Title:
A CYTOSINE ANALOGUE, A METHOD OF PREPARATION OF A CYTOSINE ANALOGUE, A DNA METHYLTRANSFERASE 1 INHIBITOR, A METHOD FOR DNA METHYLATION INHIBITION, THE USE OF THE ANALOGUE IN THE TREATMENT OF DISEASES ASSOCIATED WITH DEVIATIONS FROM NORMAL DNA METHYLATION
Document Type and Number:
WIPO Patent Application WO/2011/115513
Kind Code:
A3
Abstract:
This invention provides a cytosine analogue, a method of preparation of a cytosine analogue, a DNA rhethyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation. More precisely, the invention relates to various derivatives of cytosine, as well as methods of preparation of mono- and multi- 1,4,5 and 6-substituted cytosines. In general, the solution relates to providing effective modulators of DNA methylation which could be used in prevention and treatment of diseases associated with DNA methylation level disorders.
Inventors:
BARCISZEWSKI JAN (PL)
MARKIEWICZ WOJCIECH T (PL)
ADAMSKA EWELINA (PL)
PLITTA BEATA (PL)
GIEL-PIETRASZUK MALGORZATA (PL)
WYSZKO ELIZA (PL)
MARKIEWICZ MARIA (PL)
FEDORUK-WYSZOMIRSKA AGNIESZKA (PL)
KULINSKI TADEUSZ (PL)
CHMIELEWSKI MARCIN (PL)
MARKIEWICZ WOJCIECH T (PL)
ADAMSKA EWELINA (PL)
PLITTA BEATA (PL)
GIEL-PIETRASZUK MALGORZATA (PL)
WYSZKO ELIZA (PL)
MARKIEWICZ MARIA (PL)
FEDORUK-WYSZOMIRSKA AGNIESZKA (PL)
KULINSKI TADEUSZ (PL)
CHMIELEWSKI MARCIN (PL)
Application Number:
PCT/PL2011/000032
Publication Date:
February 23, 2012
Filing Date:
March 17, 2011
Export Citation:
Assignee:
INST CHEMII BIOORG PAN (PL)
BARCISZEWSKI JAN (PL)
MARKIEWICZ WOJCIECH T (PL)
ADAMSKA EWELINA (PL)
PLITTA BEATA (PL)
GIEL-PIETRASZUK MALGORZATA (PL)
WYSZKO ELIZA (PL)
MARKIEWICZ MARIA (PL)
FEDORUK-WYSZOMIRSKA AGNIESZKA (PL)
KULINSKI TADEUSZ (PL)
CHMIELEWSKI MARCIN (PL)
BARCISZEWSKI JAN (PL)
MARKIEWICZ WOJCIECH T (PL)
ADAMSKA EWELINA (PL)
PLITTA BEATA (PL)
GIEL-PIETRASZUK MALGORZATA (PL)
WYSZKO ELIZA (PL)
MARKIEWICZ MARIA (PL)
FEDORUK-WYSZOMIRSKA AGNIESZKA (PL)
KULINSKI TADEUSZ (PL)
CHMIELEWSKI MARCIN (PL)
International Classes:
C07H19/073; A61K31/7068; A61P35/00; C07D405/12
Domestic Patent References:
| WO2009067035A2 | 2009-05-28 |
Foreign References:
| US20060205685A1 | 2006-09-14 |
Other References:
G. F. AUDETTE ET AL: "N 4 ,5-Dimethyl-2'-deoxycytidine", ACTA CRYSTALLOGRAPHICA SECTION C CRYSTAL STRUCTURE COMMUNICATIONS, vol. 54, no. 12, 15 December 1998 (1998-12-15), pages 1987 - 1990, XP055001453, ISSN: 0108-2701, DOI: 10.1107/S0108270198008026
ZHIYONG CUI ET AL: "Semisynthesis of 3'(2')-O-(Aminoacyl)-tRNA Derivatives as Ribosomal Substrate", HELVETICA CHIMICA ACTA, vol. 90, no. 2, 1 February 2007 (2007-02-01), pages 297 - 310, XP055001488, ISSN: 0018-019X, DOI: 10.1002/hlca.200790034
ZHIYONG CUI ET AL: "Semisynthesis of 3'(2')-O-(Aminoacyl)-tRNA Derivatives as Ribosomal Substrate", HELVETICA CHIMICA ACTA, vol. 90, no. 2, 1 February 2007 (2007-02-01), pages 297 - 310, XP055001488, ISSN: 0018-019X, DOI: 10.1002/hlca.200790034
Attorney, Agent or Firm:
TWARDOWSKA, Aleksandra (Patent and Trade Mark Attorneysul. Żurawia 47/49, Warszawa, PL)
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