D-AMINO ACID OXIDASE INHIBITORS AND THERAPEUTIC USES THEREOF

Title:

D-AMINO ACID OXIDASE INHIBITORS AND THERAPEUTIC USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/076329

Kind Code:

A9

Abstract:

The present invention relates to compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: each of A, B, C, D, and E, independently, is C, N, N-H, O, S, or absent; (II) is a single bond or a double bond; each of X, Y, and Z, independently, is aryl, heteroaryl, aralkyl, H, or absent; each of L 1 and L 2, independently, is a moiety selected from O, CH 2, C=O, C 2-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, - ( (CH 2) n-W) -, wherein n=0, 1, 2, 3, 4, or 5, and W is O or S, or absent; and when L 2 is absent, Z is aryl or heteroaryl fused with (III). Also provided in the present invention is a method for inhibiting, treating and/or reducing the risk of a neuropsychiatric disorder, comprising administering a subject in need a composition comprising a compound of Formula (I).

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Inventors:

TSAI GUOCHUAN EMIL (CN)
WANG CHING-CHENG (CN)
HSIEH YUAN-TING (CN)

Application Number:

PCT/CN2018/110763

Publication Date:

August 15, 2019

Filing Date:

October 18, 2018

Export Citation:

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Assignee:

TSAI GUOCHUAN EMIL (CN)

International Classes:

C07D239/80; A61K31/517; A61P29/00

Attorney, Agent or Firm:

LIU, SHEN & ASSOCIATES (CN)

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