Title:
D-ARGININE FOR THE TREATMENT OF NEORODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO2000010546
Kind Code:
A3
Abstract:
Described is generally the modulation of apoptotic cell death. In particular, pharmaceutical compositions comprising D-arginine or an analog thereof which are particularly useful for treating, preventing and/or delaying neuronal cell death are provided. Further a method for treating, preventing and/or delaying neuronal cell death in a subject comprising administering to a subject D-arginine or an analog thereof and the use of D-arginine or an analog thereof for the preparation of pharmaceutical compositions for the treatment of neurodegenerative diseases is described. In addition, food, feed and supplements therefor comprising D-arginine or an analog thereof are provided. Furthermore, methods for identifying and obtaining neuroprotective drugs are provided.
Inventors:
CANTEROS MARIA GRISELDA (AR)
ALMEIDA OSBORNE F X (DE)
ALMEIDA OSBORNE F X (DE)
Application Number:
PCT/EP1999/006241
Publication Date:
April 17, 2003
Filing Date:
August 25, 1999
Export Citation:
Assignee:
MAX PLANCK GESELLSCHAFT (DE)
CANTEROS MARIA GRISELDA (AR)
ALMEIDA OSBORNE F X (DE)
CANTEROS MARIA GRISELDA (AR)
ALMEIDA OSBORNE F X (DE)
International Classes:
A61K31/198; A61K31/57; (IPC1-7): A61K31/195
Foreign References:
| US4789681A | 1988-12-06 | |||
| DE4311806A1 | 1994-10-06 | |||
| EP0630649A1 | 1994-12-28 |
Other References:
MASON, R.P. ET AL: "Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells", THE JOURNAL OF NEUROCHEMISTRY, vol. 72, no. 4, April 1999 (1999-04-01), pages 1448 - 1456, XP000905185
CANTEROS, M.G. ET AL: "Nitric oxide mediates dexamethasone-induced apoptosis in the dentate gyrus: The protective actions of D-arginine", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 24, no. 1-2, 1998, pages 1047, XP000905168
CORASANTI, M.T. ET AL: "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase", NEURODEGENERATION, vol. 4, no. 3, 1995, pages 315 - 321, XP000905597
WANG, JI-FENG ET AL: "Decreased production of reactive oxygen intermediates is an early event during in vitro apoptosis of rat thymocytes", FREE RADICAL BIOLOGY AND MEDICINE, vol. 20, no. 4, 1996, pages 533 - 542, XP000905498
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002137131
MATTHEWS, R.T. ET AL: "S-methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity", EXPERIMENTAL NEUROLOGY, vol. 143, no. 2, February 1997 (1997-02-01), pages 282 - 286, XP000905617
KOHNO, K. ET AL: "Intraventricular administration of nitric oxide synthase inhibitors prevents delayed neuronal cell death in gerbil hippocampal CA1 neurons", NEUROSCIENCE LETTERS, vol. 199, no. 1, 1995, pages 65 - 68, XP000905496
SHIBATA, S. ET AL: "NG-nitro-L-arginine protects against hypoxia/hypoglycemia-induced decrease in CA1 presynaptic spikes in rat hippocampal slices", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 273, no. 6, 2 June 1995 (1995-06-02), pages 223 - 228, XP000905608
FLÜGGE, G.: "Dynamics of central nervous 5-HT1A-receptors under psychosocial stress", THE JOURNAL OF NEUROSCIENCE, vol. 15, no. 11, 1995, pages 7132 - 7140, XP000905495
HASSAN, A.H.S. ET AL: "Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone", EXPERIMENTAL NEUROLOGY, vol. 140, no. 1, July 1996 (1996-07-01), pages 43 - 52, XP000905487
POW, D.V. ET AL: "Immunocytochemical analysis of the transport of arginine into nitrergic neurons and other cells in the retina and pituitary", CELL TISSUE RESEARCH, vol. 290, no. 3, December 1997 (1997-12-01), pages 501 - 514, XP000905482
FORRAY, M. I. ET AL: "Transport of nitric oxide synthase inhibitors through cationic amino acid carriers in human erythrocytes", BIOCHEMICAL PHARMACOLOGY, vol. 50, no. 12, 1995, pages 1963 - 1968, XP000905497
CANTEROS, M.G. ET AL: "Nitric oxide mediates dexamethasone-induced apoptosis in the dentate gyrus: The protective actions of D-arginine", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 24, no. 1-2, 1998, pages 1047, XP000905168
CORASANTI, M.T. ET AL: "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase", NEURODEGENERATION, vol. 4, no. 3, 1995, pages 315 - 321, XP000905597
WANG, JI-FENG ET AL: "Decreased production of reactive oxygen intermediates is an early event during in vitro apoptosis of rat thymocytes", FREE RADICAL BIOLOGY AND MEDICINE, vol. 20, no. 4, 1996, pages 533 - 542, XP000905498
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; XP002137131
MATTHEWS, R.T. ET AL: "S-methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity", EXPERIMENTAL NEUROLOGY, vol. 143, no. 2, February 1997 (1997-02-01), pages 282 - 286, XP000905617
KOHNO, K. ET AL: "Intraventricular administration of nitric oxide synthase inhibitors prevents delayed neuronal cell death in gerbil hippocampal CA1 neurons", NEUROSCIENCE LETTERS, vol. 199, no. 1, 1995, pages 65 - 68, XP000905496
SHIBATA, S. ET AL: "NG-nitro-L-arginine protects against hypoxia/hypoglycemia-induced decrease in CA1 presynaptic spikes in rat hippocampal slices", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 273, no. 6, 2 June 1995 (1995-06-02), pages 223 - 228, XP000905608
FLÜGGE, G.: "Dynamics of central nervous 5-HT1A-receptors under psychosocial stress", THE JOURNAL OF NEUROSCIENCE, vol. 15, no. 11, 1995, pages 7132 - 7140, XP000905495
HASSAN, A.H.S. ET AL: "Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone", EXPERIMENTAL NEUROLOGY, vol. 140, no. 1, July 1996 (1996-07-01), pages 43 - 52, XP000905487
POW, D.V. ET AL: "Immunocytochemical analysis of the transport of arginine into nitrergic neurons and other cells in the retina and pituitary", CELL TISSUE RESEARCH, vol. 290, no. 3, December 1997 (1997-12-01), pages 501 - 514, XP000905482
FORRAY, M. I. ET AL: "Transport of nitric oxide synthase inhibitors through cationic amino acid carriers in human erythrocytes", BIOCHEMICAL PHARMACOLOGY, vol. 50, no. 12, 1995, pages 1963 - 1968, XP000905497
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