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Title:
D-PENTOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/1997/043295
Kind Code:
A1
Abstract:
D-Pentofuranose derivatives represented by general formulae (1) to (4) and a process for the preparation of compounds of general formula (2) by oxidizing compounds of general formula (1) with a hypochlorite in the presence of a catalytic amount of a 2,2,6,6-tetramethylpiperidinoxy compound (wherein A is 4-chlorobenzoyl; R1 is hydrogen, aliphatic lower acyl or optionally substituted benzoyl; X and Y are each lower alkyl; Z is ethynyl or tri(lower alkyl)silylethynyl; and the sugar moiety of general formula (1) is xylose and those of general formulae (3) and (4) are each ribose). These compounds are useful as intermediates for the synthesis of 3'-C-substituted ribonucleoside derivatives having an excellent antitumor activity.

Inventors:
NOMURA MAKOTO (JP)
KAZUNO HIDEKI (JP)
SATO TSUTOMU (JP)
WASHINOSU MASATO (JP)
TANAKA MOTOAKI (JP)
MATSUDA AKIRA (JP)
ASAO TETSUJI (JP)
Application Number:
PCT/JP1997/001427
Publication Date:
November 20, 1997
Filing Date:
April 24, 1997
Export Citation:
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Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
NOMURA MAKOTO (JP)
KAZUNO HIDEKI (JP)
SATO TSUTOMU (JP)
WASHINOSU MASATO (JP)
TANAKA MOTOAKI (JP)
MATSUDA AKIRA (JP)
ASAO TETSUJI (JP)
International Classes:
C07H9/04; C07H13/04; C07H19/04; (IPC1-7): C07H13/06
Other References:
CARBOHYDRATE RESEARCH, (1980), Vol. 79, ROSENTHAL A. et al., "Branched-Chain Sugar Nucleosides. Synthesis of 3'-C-Ethyl(and 3'-C-Butyl)Uridine", pages 235-242.
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