DANTROLENE AQUEOUS FORMULATION AND METHOD FOR PREPARING SAME

Title:

DANTROLENE AQUEOUS FORMULATION AND METHOD FOR PREPARING SAME

Document Type and Number:

WIPO Patent Application WO/2020/049670

Kind Code:

A1

Abstract:

Provided as a technique for preparing an aqueous formulation of dantrolene or a pharmacologically acceptable salt thereof quickly and easily is a dantrolene aqueous formulation containing dantrolene or a pharmacologically acceptable salt thereof and a cyclodextrin derivative in which the amount of cyclodextrin derivative blended is from 0.5 mol to less than 2 mol per mol of dantrolene or pharmacologically acceptable salt thereof.

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Inventors:

KAWASHIMA HIROYUKI (JP)
TAKASU MASAHIRO (JP)
CHEN YI-LIN (TW)
LIU YU-SHENG (TW)

Application Number:

PCT/JP2018/032953

Publication Date:

March 12, 2020

Filing Date:

September 06, 2018

Export Citation:

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Assignee:

CMIC HOLDINGS CO LTD (JP)
ORPHANPACIFIC INC (JP)

International Classes:

A61K31/4178; A61K9/08; A61K47/69; A61P21/00

Domestic Patent References:

WO2018146187A1	2018-08-16
WO2017067980A1	2017-04-27

Foreign References:

JP2011500570A

2011-01-06

Other References:

TANAKA, RYO ET AL.: "Non-official translation: Pharmaceutical Research on Dantrolene Sodium. Anesthesia and Resuscitation. Special Volume: Advances in Malignant Hyperthermia Research II", PROCEEDINGS OF THE 2ND JAPANESE SYMPOSIUM ON MALIGNANT HYPERTHERMIA, vol. 15, no. 2, 1979, pages 101 - 108
C HEN M. ET AL.: "Preparation, characterization and in vivo evaluation of a formulation of dantrolene sodium with hydroxypropyl- beta -cyclodextrin", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 135, 19 December 2017 (2017-12-19), pages 153 - 159, XP029879694, DOI: 10.1016/j.jpba.2016.12.022

Attorney, Agent or Firm:

OHNO Seiji et al. (JP)

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