Title:
DATA ANALYSIS DEVICE
Document Type and Number:
WIPO Patent Application WO/2019/150573
Kind Code:
A1
Abstract:
According to the present invention, a first multivariable analysis processing unit (24) executes, for each sample, a first step PLS regression analysis by taking, as an explanatory variable, mass spectral data obtained for each of a plurality of measurement points in a measurement area and by taking, as an explained variable, a pixel value of a pixel corresponding to each measurement point in a fluorescent image obtained by fluorescence-labeling and capturing an image of a specific compound, and obtains a regression coefficient matrix. A second multivariable analysis processing unit (25) executes a second step PLS regression analysis by taking, as an explanatory variable, a result obtained by integrating a plurality of one-dimensional regression coefficient matrices obtained for a plurality of samples and by taking, as an explained variable, information indicating the severity of cancer in each sample as information indicating a state of each sample, and obtains a regression coefficient matrix again. Accordingly, new information, which is hard to obtain in a conventional manner, can be acquired, the new information including information that pertains to a compound or the like indicating a change in amount according to the severity of cancer among compounds indicating a distribution similar to that of the specific compound on the fluorescent image.
Inventors:
YAMAGUCHI SHINICHI (JP)
Application Number:
PCT/JP2018/003757
Publication Date:
August 08, 2019
Filing Date:
February 05, 2018
Export Citation:
Assignee:
SHIMADZU CORP (JP)
International Classes:
G01N27/62
Domestic Patent References:
| WO2017002226A1 | 2017-01-05 | |||
| WO2014175211A1 | 2014-10-30 |
Foreign References:
| JP2017224283A | 2017-12-21 |
Other References:
SHINMA, SHUICHI: "Analysis of cancer heterogeneity using imaging mass microscope", EXPERIMENTAL MEDICINE, vol. 36/2, 1 February 2018 (2018-02-01), pages 211 - 217
Attorney, Agent or Firm:
KYOTO INTERNATIONAL PATENT LAW OFFICE (JP)
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