Title:
DEATH DOMAIN PROTEINS
Document Type and Number:
WIPO Patent Application WO2002040680
Kind Code:
A3
Abstract:
In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NR-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention DDs, DEDs or NB-ARC domains. Such DDs, DEDs and NBARC domains and/or anti-DD, anti-DED or anti-NB-ARC domain antibodies are useful for discovery of drugs that suppress infection, autoimmunity, inflammation, allergy, allograft rejection, sepsis, and other diseases.
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Inventors:
REED JOHN C (US)
GODZIK ADAM (US)
PAWLOWSKI KRZYSZTOF (SE)
FIORENTINO LOREDANA (US)
LEE SUG HYUNG (US)
ROTH WILFRIED (US)
STENNER-LIEWEN FRANK (US)
GODZIK ADAM (US)
PAWLOWSKI KRZYSZTOF (SE)
FIORENTINO LOREDANA (US)
LEE SUG HYUNG (US)
ROTH WILFRIED (US)
STENNER-LIEWEN FRANK (US)
Application Number:
PCT/US2001/044844
Publication Date:
March 13, 2003
Filing Date:
November 15, 2001
Export Citation:
Assignee:
BURNHAM INST (US)
REED JOHN C (US)
GODZIK ADAM (US)
PAWLOWSKI KRZYSZTOF (SE)
FIORENTINO LOREDANA (US)
LEE SUG HYUNG (US)
ROTH WILFRIED (US)
STENNER-LIEWEN FRANK (US)
REED JOHN C (US)
GODZIK ADAM (US)
PAWLOWSKI KRZYSZTOF (SE)
FIORENTINO LOREDANA (US)
LEE SUG HYUNG (US)
ROTH WILFRIED (US)
STENNER-LIEWEN FRANK (US)
International Classes:
C07K14/295; C07K14/47; C12N15/31; (IPC1-7): C12N15/31; C07K14/295; C07K16/12; C12N15/62; C12Q1/68; G01N33/53; G01N33/68
Domestic Patent References:
| WO1995010630A1 | 1995-04-20 | |||
| WO1998039429A2 | 1998-09-11 | |||
| WO2001051641A1 | 2001-07-19 | |||
| WO2000020587A2 | 2000-04-13 | |||
| WO1997000690A1 | 1997-01-09 | |||
| WO1999027112A1 | 1999-06-03 |
Other References:
BERGER THORSTEN ET AL: "The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins.", JOURNAL OF CELL SCIENCE, vol. 113, no. 20, October 2000 (2000-10-01), pages 3603 - 3612, XP002208992, ISSN: 0021-9533
HOFMANN K: "The modular nature of apoptotic signaling proteins.", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 55, no. 8-9, July 1999 (1999-07-01), pages 1113 - 1128, XP002171651, ISSN: 1420-682X
KISSIL ET AL: "Isolation of DAP3,", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 46, no. 270, 1995, pages 27932 - 27936, XP002080572, ISSN: 0021-9258
REED JOHN C ET AL: "Drug discovery opportunities from apoptosis research.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 11, no. 6, December 2000 (2000-12-01), pages 586 - 592, XP002208993, ISSN: 0958-1669
PARK SEUNG YONG ET AL: "Establishment of a high-throughput screening system for caspase-3 inhibitors.", ARCHIVES OF PHARMACAL RESEARCH (SEOUL), vol. 23, no. 3, June 2000 (2000-06-01), pages 246 - 251, XP001098281, ISSN: 0253-6269
STEGH AH ET AL: "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 17, no. 20, 15 October 1998 (1998-10-15), pages 5974 - 5986, XP002130084, ISSN: 0261-4189
HAN D K M ET AL: "MRIT, A NOVEL DEATH-EFFECTOR DOMAIN-CONTAINING PROTEIN, INTERACTS WITH CASPASES AND BCLXL AND INITIATES CELL DEATH", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 21, 14 October 1997 (1997-10-14), pages 11333 - 11338, XP002071904, ISSN: 0027-8424
FEINSTEIN E ET AL: "The death domain: a module shared by proteins with diverse cellular functions", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 20, no. 9, September 1995 (1995-09-01), pages 342 - 344, XP004212795, ISSN: 0968-0004
BIEZEN VAN DER E A ET AL: "THE NB-ARC DOMAIN: A NOVEL SIGNALLING MOTIF SHARED BY PLANT RESISTANCE GENE PRODUCTS AND REGULATORS OF CELL DEATH IN ANIMALS", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 8, no. 7, 26 March 1998 (1998-03-26), pages 226 - 227, XP000986552, ISSN: 0960-9822
KUMAR D ET AL: "IDENTIFICATION OF A NOVEL TUMOR NECROSIS FACTOR-ALPHA-INDUCIBLE GENE, SCC-S2, CONTAINING THE CONSENSUS SEQUENCE OF A DEATH EFFECTOR DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN-LIKE INTERLEUKIN-1BETA-CONVERTING ENZYME-INHIBITORY PROTEIN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 4, no. 275, 28 January 2000 (2000-01-28), pages 2973 - 2978, XP002909768, ISSN: 0021-9258
LIANG H ET AL: "Three-dimensional structures of proteins involved in programmed cell death.", JOURNAL OF MOLECULAR BIOLOGY. ENGLAND 5 DEC 1997, vol. 274, no. 3, 5 December 1997 (1997-12-05), pages 291 - 302, XP002208994, ISSN: 0022-2836
DATABASE SWALL [online] trEMBL; 1 November 1999 (1999-11-01), SCANLAN MJ ET AL.: "Hypothetical protein", XP002218301, retrieved from SWALL accession no. Q9Y589 Database accession no. Q9Y589
DATABASE EMBL [online] 22 February 2000 (2000-02-22), SUGANO S ET AL.: "Homo sapiens cDNA", XP002218302, retrieved from EMBL accession no. AK000528 Database accession no. AK000528
DATABASE SWALL [online] trEMBL; 1 October 2000 (2000-10-01), STRAUSBERG R., AND WATANABE K ET AL.: "Hypothetical protein FLJ20521", XP002218303, retrieved from SWALL accession no. Q9WZ3 Database accession no. Q9NWZ3
WESCHE HOLGER ET AL: "IRAK-M is a novel member of the pelle/interleukin-1 receptor-associated kinase (IRAK) family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 27, 2 July 1999 (1999-07-02), pages 19403 - 19410, XP002218299, ISSN: 0021-9258
KANAKARAJ PALANISAMY ET AL: "Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 12, 15 June 1998 (1998-06-15), pages 2073 - 2079, XP002218300, ISSN: 0022-1007
HOFMANN K: "The modular nature of apoptotic signaling proteins.", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 55, no. 8-9, July 1999 (1999-07-01), pages 1113 - 1128, XP002171651, ISSN: 1420-682X
KISSIL ET AL: "Isolation of DAP3,", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 46, no. 270, 1995, pages 27932 - 27936, XP002080572, ISSN: 0021-9258
REED JOHN C ET AL: "Drug discovery opportunities from apoptosis research.", CURRENT OPINION IN BIOTECHNOLOGY, vol. 11, no. 6, December 2000 (2000-12-01), pages 586 - 592, XP002208993, ISSN: 0958-1669
PARK SEUNG YONG ET AL: "Establishment of a high-throughput screening system for caspase-3 inhibitors.", ARCHIVES OF PHARMACAL RESEARCH (SEOUL), vol. 23, no. 3, June 2000 (2000-06-01), pages 246 - 251, XP001098281, ISSN: 0253-6269
STEGH AH ET AL: "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 17, no. 20, 15 October 1998 (1998-10-15), pages 5974 - 5986, XP002130084, ISSN: 0261-4189
HAN D K M ET AL: "MRIT, A NOVEL DEATH-EFFECTOR DOMAIN-CONTAINING PROTEIN, INTERACTS WITH CASPASES AND BCLXL AND INITIATES CELL DEATH", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 21, 14 October 1997 (1997-10-14), pages 11333 - 11338, XP002071904, ISSN: 0027-8424
FEINSTEIN E ET AL: "The death domain: a module shared by proteins with diverse cellular functions", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 20, no. 9, September 1995 (1995-09-01), pages 342 - 344, XP004212795, ISSN: 0968-0004
BIEZEN VAN DER E A ET AL: "THE NB-ARC DOMAIN: A NOVEL SIGNALLING MOTIF SHARED BY PLANT RESISTANCE GENE PRODUCTS AND REGULATORS OF CELL DEATH IN ANIMALS", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 8, no. 7, 26 March 1998 (1998-03-26), pages 226 - 227, XP000986552, ISSN: 0960-9822
KUMAR D ET AL: "IDENTIFICATION OF A NOVEL TUMOR NECROSIS FACTOR-ALPHA-INDUCIBLE GENE, SCC-S2, CONTAINING THE CONSENSUS SEQUENCE OF A DEATH EFFECTOR DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN-LIKE INTERLEUKIN-1BETA-CONVERTING ENZYME-INHIBITORY PROTEIN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 4, no. 275, 28 January 2000 (2000-01-28), pages 2973 - 2978, XP002909768, ISSN: 0021-9258
LIANG H ET AL: "Three-dimensional structures of proteins involved in programmed cell death.", JOURNAL OF MOLECULAR BIOLOGY. ENGLAND 5 DEC 1997, vol. 274, no. 3, 5 December 1997 (1997-12-05), pages 291 - 302, XP002208994, ISSN: 0022-2836
DATABASE SWALL [online] trEMBL; 1 November 1999 (1999-11-01), SCANLAN MJ ET AL.: "Hypothetical protein", XP002218301, retrieved from SWALL accession no. Q9Y589 Database accession no. Q9Y589
DATABASE EMBL [online] 22 February 2000 (2000-02-22), SUGANO S ET AL.: "Homo sapiens cDNA", XP002218302, retrieved from EMBL accession no. AK000528 Database accession no. AK000528
DATABASE SWALL [online] trEMBL; 1 October 2000 (2000-10-01), STRAUSBERG R., AND WATANABE K ET AL.: "Hypothetical protein FLJ20521", XP002218303, retrieved from SWALL accession no. Q9WZ3 Database accession no. Q9NWZ3
WESCHE HOLGER ET AL: "IRAK-M is a novel member of the pelle/interleukin-1 receptor-associated kinase (IRAK) family.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 27, 2 July 1999 (1999-07-02), pages 19403 - 19410, XP002218299, ISSN: 0021-9258
KANAKARAJ PALANISAMY ET AL: "Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 12, 15 June 1998 (1998-06-15), pages 2073 - 2079, XP002218300, ISSN: 0022-1007
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