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Title:
DECONTAMINATION FORMULATION
Document Type and Number:
WIPO Patent Application WO/2018/232281
Kind Code:
A1
Abstract:
An enhanced chemical formulation designed for the decontamination, disinfection and renewal of surfaces exposed to chemical, biological and toxic industrial contaminants and residues. This formula improves on prior art by expanding the efficacy spectrum, decreasing treatment time, modifying chemical properties allowing for lower effective dosage and broadening the roster of chemical agents remediated by it. The formulation described herein may also be applied in variable concentrations to achieve decontamination objectives (cleaning, sanitization, disinfection, high level disinfection, mold remediation, biofilm remediation, targeted decontamination).

Inventors:
BLUHM, Matthew, A. (8541 East Anderson Drive, Suite 106Scottsdale, AZ, 85255, US)
STARBUCK, Brian (8541 East Anderson Drive, Suite 106Scottsdale, AZ, 85255, US)
Application Number:
US2018/037817
Publication Date:
December 20, 2018
Filing Date:
June 15, 2018
Export Citation:
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Assignee:
DECON7 SYSTEMS, LLC (8541 East Anderson Drive, Suite 106Scottsdale, AZ, 85255, US)
International Classes:
A61L2/16; A61L2/18; A62D3/00
Domestic Patent References:
WO2011156398A12011-12-15
Foreign References:
US7125497B12006-10-24
Other References:
BETTY R. G. ET AL.: "Enhanced Micellar Catalysis LDRD", SANDIA REPORT SAND2012-10608, December 2012 (2012-12-01), pages 1 - 61, XP055556342, Retrieved from the Internet [retrieved on 20180802]
SINGH ET AL.: "Decontamination of Chemical Warfare Agents", DEFENCE SCIENCE JOURNAL, vol. 60, no. 4, July 2010 (2010-07-01), pages 428 - 441, XP055556346, Retrieved from the Internet [retrieved on 20180802]
Attorney, Agent or Firm:
YUAN, Arthur, T. (Loeb & Loeb LLP, 321 N. Clark StreetSuite 230, Chicago IL, 60654, US)
Download PDF:
Claims:
What is claimed is:

1. An enhanced chemical formulation comprising a mixture of:

Part A:

BTC 888 (80 % active ingredient) 32% (40% C12, 50% C14, 10% C16) + 48% of DADMAC at about a range of 0.1 to 4.00% of the mixture;

Adogen 477D (50% Active ingredient) at about a range of 0.05 to 2.00% of the mixture;

Glycol Ether DB at about a range of 0.4 to 1.60% of the mixture;

Isobutanol at about a range of 0.025 to 1.00% of the mixture;

Propylene Glycol at about a range of 0.5 to 20.00% of the mixture;

Lauryl Alcohol at about a range of 0.02 to 0.80% of the mixture;

Potassium Bicarb USP Anhyd at about a range of 0.3 to 12.00%) of the mixture;

Caustic Potashat about a range of 0.0425 to 1.70% of the mixture; and

Water at about a range of 56.90 to 98.56% of the mixture;

Part B

Hydrogen peroxide at about a range of 0.2 to 8.00% of the mixture

Inerts and stabilizers and Water at about a range of 99.8 to 85% of the mixture; and

Part C:

Bleaching accelerator at about a range of 0.05 to 2.00% of the mixture

2. The formulation of claim 1, wherein the mixture comprises a ratio of Part A, Part B and Part C according to the following: 49 g of Part A, 49 g of Part B, and 2 g of Part C.

3. The formulation of claim 1, wherein the mixture comprises a ratio of Part A and Part B according to the following: 50 g of Part A and 50 g of Part B.

4. A decontamination formulation comprises a mixture of Part A, Part B, and Part C, wherein:

Part A comprises:

Benzyl-C12-C16 Alkyl Di-Methyl Ammonium Chloride (Variquat 80MC) ;

N,N,N,N',N'-Pentamethyl-N' Tallow Alkyl-Trimethlyenedi-,chlorides (Adogen 477);

PEG 8000 or equivalent (i.e., Jaguar 8000);

Di-ethylene Glycol Monobutyl Ether;

Lauryl Alcohol;

Isobutanol;

Potassium Bicarbonate/Potassium Carbonate;

Propylene Glycol; and

DI Water;

wherein Part B comprises:

Hydrogen peroxide; and

DI Water; and

wherein Part C comprises:

Glycerol Diacetate (Diacetin);

wherein the mixture comprises a ratio of 49 g of Part A, 49 g of Part B, and 2 g of Part C.

5. A decontamination formulation comprises a mixture of Part A and Part B, wherein:

Part A comprises: Benzyl-C12-C16 Alkyl Di-Methyl Ammonium Chloride (Variquat 80MC) ;

N,N,N,N',N'-Pentamethyl-N' Tallow Alkyl-Trimethlyenedi-,chlorides (Adogen 477);

PEG 8000 or equivalent (i.e., Jaguar 8000);

Di-ethylene Glycol Monobutyl Ether;

Lauryl Alcohol;

Isobutanol;

Potassium Bicarbonate/Potassium Carbonate;

Propylene Glycol; and

DI Water;

wherein Part B comprises:

Hydrogen peroxide; and

DI Water; and

wherein the mixture comprises a ratio of 50 g of Part A, 50 g of Part B.

Description:
DECONTAMINATION FORMULATION

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This is a PCT international application claiming priority to a US provisional patent application, serial number 62/520,372, filed on June 15, 2017, whose disclosure is incorporated by reference in its entirety herein. The present application further claims priority to the following US provisional applications: Serial No. 62/618,095; Serial No. 62/618,096; Serial No. 62/618,098; Serial No. 62/618,100; and Serial No. 62/618,104, all filed on January 17, 2018, whose disclosures are incorporated by reference in their entirety herein.

BACKGROUND

[0002] Industrial cleaning solutions have been available to decontamination materials.

However, depending on the type of surfaces the materials rest on, the effectiveness of the decontamination solutions vary. Also, the amount of time needed for the solutions to react with the materials can be critical as well. Therefore, there is a need to a new combinations of solutions that can achieve various decontamination objectives.

SUMMARY

[0003] Embodiments of the invention describe an enhanced chemical formulation

designed for the decontamination, disinfection and renewal of surfaces exposed to chemical, biological and toxic industrial contaminants and residues. This formula improves on prior art by expanding the efficacy spectrum, decreasing treatment time, modifying chemical properties allowing for lower effective dosage and broadening the roster of chemical agents remediated by it. The formulation described herein may also be applied in variable concentrations to achieve decontamination objectives (cleaning, sanitization, disinfection, high level disinfection, mold remediation, biofilm remediation, targeted decontamination).

[0004] As such, one embodiment of the invention provides an improved formulation with a broadened efficacy spectrum. In another embodiment, a chemical formulation provides an improved formulation capable of being modulated to tactical necessity. A further embodiment provides an improved formulation with residual sanitization affects. An alternative embodiment provides an improved formulation for the specific treatment of biofilms. Furthermore, another embodiment provides an improved formulation for the disinfection of pathogenic spores. Additional embodiment provides an improved formulation enabling the application of disinfection/decontamination efficacy using electrostatic spray technology for improved surface coverage. In another aspect, embodiments of the invention provide an improved formulation permitting a lower surface dosage with increased biocidal and decontamination activity.

BRIEF DESCRIPTION OF DRAWINGS

[0005] FIG. 1 illustrates a diagram showing various uses of the present invention

according to one embodiment of the invention.

DETAILED DESCRIPTION

[0006] Embodiments of the invention describe an enhanced chemical formulation

designed for the decontamination, disinfection and renewal of surfaces exposed to chemical, biological and toxic industrial contaminants and residues. This formula improves on prior art by expanding the efficacy spectrum, decreasing treatment time, modifying chemical properties allowing for lower effective dosage and broadening the roster of chemical agents remediated by it. The formulation described herein may also be applied in variable concentrations to achieve decontamination objectives (cleaning, sanitization, disinfection, high level disinfection, mold remediation, biofilm remediation, targeted decontamination).

[0007] Embodiments of the invention further aim to incremental variants designed to perform particular tasks is the intent of this effort. In one embodiment, aspects of the invention may be formulated with a Generation 1 version of Quaternary amine

(ADBAC). It is shown that broadening the type of quaternary amine brings, in one example, a benefit in both efficacy against a broader range pathogens or and greater effectiveness against biofilms. Of the two, biofilm effectiveness is likely the prominent value proposition.

[0008] Taking a view of the relationship of the quat generation, the following

comparison is relevant.

[0009] In one embodiment, aspects of the invention focus on Generation 5 Quaternary Amine. This category is a mixture of generation 1 and generation 4. The innovation options may rapidly multiply when one considers permutations of different generation 1 chemistries along with the generation 4 variants. Table 1 includes some of the most accessible options:

Stepan BTC-888 80% Active Different foaming characteristics, different efficacy

32% CAS profile, different physiochemical performance

Pilot MQ- 68424-85-1

624M 48% Variable

dialkyl,

dimethyl

Table 1

[0010] In one embodiment, the following Table 2 illustrates a chemical formulation achieving exemplary results:

Inerts and stabilizers

Water 99.8 to 85%

Part C Formulation Ingredient Prescribed amount

Bleaching accelerator 0.05 to 2.00%

Table 2

[0011] In one embodiment, the formulation mixes the Parts above in the following ratio: 49 g of Part A, 49 g of Part B, and 2 g of Part C. In another alternative mixing for a 2-part formulation, one embodiment of the mixture includes 50 g of Part A and 50 g of Part B.

[0012] This embodiment of the invention may have, in one example, different physiochemical properties related to the potency of the surfactant in its ability to solubilize targeted agents, promote the disruption of biofilm protective structures and deliver cidal efficacy to pathogenic organisms. The efficacy profile of this version may also be different. The development of the efficacy profile should be from a dilute version, perhaps a 1 to 100 dilution of the final product, up to the full version. The dilute version might be considered for surfaces that are already clean and devoid of biofilm presence. In one embodiment, the concentrated version would be considered for circumstances where gross filth is more prevalent (live animal facilities, processing plants, high biofilm potential places). Various embodiments of the invention for different dilutions (bacteria, biofilm, fogging efficacy) may enable various levels of applications in addition to those disclosed in FIG. 1.

[0013] In another embodiment, the formulation in Table 3 may include the following:

Table 3

[0014] In one embodiment, the formulation mixes the Parts above in the following ratio:

49 g of Part A, 49 g of Part B, and 2 g of Part C. In another alternative mixing for a 2-part formulation, one embodiment of the mixture includes 50 g of Part A and 50 g of Part B.

[0015] These improvements upon prior art enables the contemplation of a full spectrum product capable of dealing with sensitive cleaning and sanitization situations like those encountered in food contact and public health circumstances. In those circumstances, a product may be able to be applied to a target surface usually as a spray and wiped down distributing the cleaning/sanitization/decontamination formulation over the entire surface. In one embodiment, aspects of the invention may need to receive approval from regulatory oversight agencies before use. In this case, this is commonly known as a "leave-on" product. There are statutory limits of labeled ingredients permissible for this type of use. It is an embodied intention of this improvement to enable this type of use. A full strength version of the product is intended for use in highly compromised

environments like live animal barns where significant gross filth is anticipated. This represents the other end of the product spectrum. Regulatory oversight is also a requisite in relation to pesticidal embodiments. It is anticipated that there will be many situations in between these two extremes where a strength modulated product would serve the need. Examples of such situations are given in spectrum above.

[0016] In one example, a lab test illustrates a representative sample of the predicate

formulation was evaluated for its ability to treat an archetype of commonly encountered filth, bacon grease. In a controlled experiment, an aliquot of bacon grease was treated with no mechanical impulse in 176 seconds using the predicate.

[0017] The improved variant treated and eliminated the same aliquot of bacon grease in 156 seconds, a 10% improvement. The measured reduction in interfacial tension between the bacon grease object and the improved formula testifies to its improved surfactant potency. The reduction of interfacial tension between nonpolar targets like bacon grease and the decontamination agent is one of the critical metric used in formulary

optimization. This improvement translates into significant operational gain. As to be tested and shown in test results, embodiments of the invention provide advantages and superiority in treatment time or exposure time of the mixture on the targeted material in 10-minute, 5-minute and 2 minute test conditions.

[0018] Enhanced efficacy potency against biofilm contagions were also measured in another lab test. Biofilms are more challenging to treat by virtue of their protective encasement. This protective encasement is hydrophobic in nature and demands a more aggressive treatment to penetrate down to the protected bacteria housed underneath. One variant improved biofilm efficacy by a certain degree, with the test data to support such conclusion of additional data. A more diluted version of the formula was able to treat the film thus presenting a significant value proposition to users.

[0019] It is readily apparent to those skilled in the art that small formulary modifications can yield significant, measurable and effective reduction of interfacial tension between an object and the cleaning agent. This formula can be throttled and designed to adapt to a myriad of surfaces and targets.

[0020] The foregoing description and drawings merely explain and illustrate the

invention and the invention is not limited thereto. While the specification is described in relation to certain implementation or embodiments, many details are set forth for the purpose of illustration. Thus, the foregoing merely illustrates the principles of the invention. For example, the invention may have other specific forms without departing from its spirit or essential characteristic. The described arrangements are illustrative and not restrictive. To those skilled in the art, the invention is susceptible to additional implementations or embodiments and certain of these details described in this application may be varied considerably without departing from the basic principles of the invention. It will thus be appreciated that those skilled in the art will be able to devise various arrangements which, although not explicitly described or shown herein, embody the principles of the invention and, thus, within its scope and spirit.

[0021] While various embodiments have been described above, it should be understood that such disclosures have been presented by way of example only and are not limiting. Thus, the breadth and scope of the subject compositions and methods should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents.

2] Having now fully described the subject compositions and methods, it will be understood by those of ordinary skill in the art that the same can be performed within a wide and equivalent range of conditions, formulations and other parameters without affecting their scope or any embodiment thereof. All cited patents, patent applications and publications are fully incorporated by reference in their entirety.