Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
DECOY LIBRARY CONSTRUCTION METHOD AND APPARATUS, TARGET-DECOY LIBRARY CONSTRUCTION METHOD AND APPARATUS, AND METABOLOME FDR IDENTIFICATION METHOD AND APPARATUS
Document Type and Number:
WIPO Patent Application WO/2021/004355
Kind Code:
A1
Abstract:
Disclosed are a decoy library construction method and apparatus, a target-decoy library construction method and apparatus and a metabolome FDR identification method and apparatus. The decoy library construction method comprises: S1, respectively comparing a mass-to-charge ratio M of a parent ion of a metabolite of each spectrogram in a target database with those of all other spectrograms in the target database one by one, storing a spectrogram, a mass-to-charge ratio of a daughter ion of which is equal to M, and/or the serial number of the spectrogram in a signal spectrum index array, and generating a signal spectrum index two-dimensional array; S2, traversing all elements in the signal spectrum index two-dimensional array to obtain n arrays D, wherein the n arrays D constitute a decoy library signal array; and S3, copying parent ion information of the spectrogram, corresponding to each sub-set in the decoy library signal array, in the target database to the decoy library signal array to form a decoy library. By means of the metabolome identification method, FDR quality control can be carried out on an identification result, and a spectrogram can be quickly identified in high throughput, thereby improving the utilization rate of the spectrogram and the coverage of metabolite identification.

Inventors:
LI DEHUA (CN)
LI WEI (CN)
LUAN ENHUI (CN)
LONG QIAOYUN (CN)
SONG JIAPING (CN)
LI ZHENYU (CN)
WANG YALAN (CN)
Application Number:
PCT/CN2020/099769
Publication Date:
January 14, 2021
Filing Date:
July 01, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SHENZHEN WEBIO CO LTD (CN)
SHENZHEN DIGITAL LIFE INST (CN)
International Classes:
G01N33/68
Domestic Patent References:
WO2018138901A12018-08-02
Foreign References:
CN101871945A2010-10-27
CN104034792A2014-09-10
CN102495127A2012-06-13
CN105334279A2016-02-17
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
Download PDF: