Title:
DEEP GRADIENT-DENSITY FILTER DEVICE
Document Type and Number:
WIPO Patent Application WO2004060535
Kind Code:
A3
Abstract:
The present invention provides a deep gradient-density filter device capable of effectively filtering a fluid containing a distribution of particles in the range of approximately 25 microns to approximately 0.2 micron at a fluid velocity of at least approximately 100 cm/hr and an initial hydraulic permeability of greater than approximately 10 cm/hr/psi. The deep gradient-density filter device comprises several layers of filtration material, each having specific predetermined particle retention properties. In one product embodiment of the present invention, the deep gradient-density filter device uses "loose" fibrillated cellulose fiber material as a primary filter element. In a method aspect of the invention, the deep gradient-density filter device is used for either the secondary clarification of industrial-scale cultured or fermented protein-containing biopharmaceutical fluids or the primary clarification of pilot-scale volumes of said fluids.
Inventors:
YAVORSKY DAVID P
ROYCE JONATHAN
ALEXANDER MATTHEW
RAMAN VEN ANANTHA
ROYCE JONATHAN
ALEXANDER MATTHEW
RAMAN VEN ANANTHA
Application Number:
PCT/US2003/038630
Publication Date:
January 27, 2005
Filing Date:
December 04, 2003
Export Citation:
Assignee:
MILLIPORE CORP (US)
International Classes:
B01D39/16; B01D39/18; (IPC1-7): B01D39/16; B01D39/18
Foreign References:
| GB1271867A | 1972-04-26 | |||
| US5716522A | 1998-02-10 | |||
| US4714647A | 1987-12-22 |
Other References:
See also references of EP 1572320A2
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