DEFECTIVE PACKAGING NON-ONCOVIRAL VECTORS BASED ON MPMV AND HIV

WIPO Patent Application WO1993017118

A3

The present invention relates to vectors and their use in gene transfer, In particular the invention provides a vector comprising nucleotides corresponding to the packaging nucleotides of a lentivirus, a heterologous gene, and, flanking the packaging nucleotide and the heterologous gene, sequences corresponding to those within and near the sufficient lentivirus LTR, for packaging, reverse transcription and integration of the vector into target cells and expression of the heterologous gene wherein said nucleotides comprise those corresponding at least substantially to the lentivirus 5' leader sequence and REV-responsive region.

LEVER ANDREW MICHAEL LINDSAY (GB)
HUNTER ERIC (GB)

PCT/GB1993/000417

October 14, 1993

March 01, 1993

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LEVER ANDREW M L (GB)
HUNTER ERIC (GB)

C12N15/09; A61K35/76; A61K48/00; A61P43/00; C07K14/15; C07K14/16; C12N7/04; C12N15/38; C12N15/39; C12N15/867; A61K39/00; (IPC1-7): C12N15/86; C12N7/04; C12N15/38; C12N15/39

WO1991019798A1

1991-12-26

VIROLOGY vol. 189, no. 2, August 1992, pages 786 - 791 VILE, R.G. ET AL. 'Identification of a generalised packaging sequence for D-type retroviruses and generation of a D-type retroviral vector'
FRANKI, R. ET AL. 'Classification and nomenclature of viruses (5th Report of the International Committee on Taxonomy of Viruses' 1992 , SPRINGER-VERLAG , WIEN, AU

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