Title:
DEGRADABLE COMPOUNDS AND METHODS OF USE THEREOF, PARTICULARLY WITH PARTICLE REPLICATION IN NON-WETTING TEMPLATES
Document Type and Number:
WIPO Patent Application WO/2009/132265
Kind Code:
A3
Abstract:
The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile -Si-A-C- groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C=O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.
Inventors:
DESIMONE JOSEPH (US)
PARROTT MATTHEW (US)
MURPHY ANDREW (US)
PETROS ROBBY A (US)
PARROTT MATTHEW (US)
MURPHY ANDREW (US)
PETROS ROBBY A (US)
Application Number:
PCT/US2009/041652
Publication Date:
February 24, 2011
Filing Date:
April 24, 2009
Export Citation:
Assignee:
UNIV NORTH CAROLINA (US)
LIQUIDIA TECHNOLOGIES INC (US)
DESIMONE JOSEPH (US)
PARROTT MATTHEW (US)
MURPHY ANDREW (US)
PETROS ROBBY A (US)
LIQUIDIA TECHNOLOGIES INC (US)
DESIMONE JOSEPH (US)
PARROTT MATTHEW (US)
MURPHY ANDREW (US)
PETROS ROBBY A (US)
International Classes:
A61K31/00; B82B1/00; C07F7/08
Foreign References:
| EP1201672A2 | 2002-05-02 | |||
| EP0525392A1 | 1993-02-03 | |||
| US6121404A | 2000-09-19 | |||
| CH569029A5 | 1975-11-14 | |||
| EP0754691A2 | 1997-01-22 | |||
| DE2044888A1 | 1971-03-11 |
Other References:
EFROSYNI THEMISTOU AND COSTAS S. PATRICKIOS: "Synthesis and Characterization of Star Polymers and Cross-Linked Star Polymer Model Networks Containing a Novel, Silicon-Based, Hydrolyzable Cross-Linker", MACROMOLECULES, vol. 37, no. 18, 2004, pages 6734 - 6743, XP002533454
"Silicon Compounds", 2004, GELEST, XP002533455
"Silicon Compounds", 2004, GELEST, XP002533455
Attorney, Agent or Firm:
CAGLE, Ryan W. et al. (Bank Of America Plaza101 South Tryon Street, Suite 400, Charlotte NC, US)
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