DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOMPATIBILITY FOR SOFT TISSUE REGENERATION

WIPO Patent Application WO2007101443

A8

The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR¹CHR²O)_n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH₃)-COO-] and (ii) glycolide units [-CH₂-COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C_1-6-alkyl or hydroxy protecting groups, one of R¹ and R² is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR¹CHR²O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

VANGE JAKOB (DK)
SCHWACH-ABDELLAOUI KHADIJA (DK)
EVERLAND HANNE (DK)
NIELSEN PETER SYLVEST (DK)
NIELSEN BRIAN (DK)
JESPERSEN LENE KARIN (DK)
NIELSEN LENE FELDSKOV (DK)

PCT/DK2007/000115

November 08, 2007

March 07, 2007

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COLOPLAST AS (DK)
VANGE JAKOB (DK)
SCHWACH-ABDELLAOUI KHADIJA (DK)
EVERLAND HANNE (DK)
NIELSEN PETER SYLVEST (DK)
NIELSEN BRIAN (DK)
JESPERSEN LENE KARIN (DK)
NIELSEN LENE FELDSKOV (DK)

C08G63/664; A61L15/26; A61L27/18; A61L27/56; C08G81/00; C08J9/00; C08J9/28

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