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Title:
DEGRADABLE POLYETHYLENE GLYCOL CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2019/189853
Kind Code:
A1
Abstract:
Provided is a biologically relevant substance to which is bonded a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation in cells. A biologically relevant substance to which is bonded a degradable polyethylene glycol derivative that is represented by formula (A). (In the formula, m is 1–7, n1 and n2 are each independently 45–682, p is 1–4, R is a C1–4 alkyl group, Z is a 2–8-residue oligopeptide that comprises neutral amino acids other than cysteine, Q is a residue of a compound that has 2–5 active hydrogens, D is the biologically relevant substance, L1, L2, L3, L4, and L5 are each independently a single bond or a bivalent space, and y is 1–40.)

Inventors:
YOSHIOKA, Hiroki (3-3 Chidori-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 65, 〒2100865, JP)
KAMIYA, Masaki (3-3 Chidori-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 65, 〒2100865, JP)
YAMAMOTO, Yuji (3-3 Chidori-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 65, 〒2100865, JP)
HIRAI, Midori (3-3 Chidori-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 65, 〒2100865, JP)
SASAKI, Akiko (3-3 Chidori-cho, Kawasaki-ku, Kawasaki-sh, Kanagawa 65, 〒2100865, JP)
NISHIYAMA, Nobuhiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
MATSUI, Makoto (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
TAKEMOTO, Hiroyasu (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
MIYAUCHI, Kazuki (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
NOMOTO, Takahiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
TOMODA, Keishiro (2-12-1 Ookayama, Meguro-k, Tokyo 50, 〒1528550, JP)
Application Number:
JP2019/014245
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
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Assignee:
NOF CORPORATION (20-3, Ebisu 4-chome Shibuya-k, Tokyo 19, 〒1506019, JP)
TOKYO INSTITUTE OF TECHNOLOGY (2-12-1, Ookayama Meguro-k, Tokyo 50, 〒1528550, JP)
International Classes:
C07K14/585; A61K47/60; A61P43/00; C07K5/06; C07K5/08; C07K5/10; C07K7/06; C07K14/535; C07K14/61; C08G65/329
Domestic Patent References:
WO2006088248A12006-08-24
Foreign References:
JP2003104913A2003-04-09
JP2003528939A2003-09-30
JP2007112924A2007-05-10
JP2002543111A2002-12-17
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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