Title:
DEGRADABLE TWO-COMPONENT HYDROGEL, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/170681
Kind Code:
A1
Abstract:
The present invention relates to a degradable two-component hydrogel, and a preparation method therefor and the use thereof. The degradable two-component hydrogel is prepared by means of mixing a component A, a component B and a solvent, the component A is a degradable macromolecule derivative modified with an o-phthalaldehyde molecule, the component B is a water-soluble micromolecule, water-soluble synthetic macromolecule or polysaccharide containing one or more groups of primary amine, diamine, hydrazide, hydroxylamine and sulfydryl, and the number of groups contained is not less than 2. In the present invention, a degradable structure is introduced into the macromolecule framework of the component A, so that regulation and control over the degradable performance of the prepared hydrogel is realized, and a hydrogel with a rapid degradation rate is obtained, thus overcoming the current application bottleneck of the common raw materials for preparing a two-component hydrogel either struggling to degrade a polyethylene glycol framework or bringing potential safety hazards due to the requirement of introducing other degradable biological products. Moreover, the hydrogel provided by the present invention has a simple preparation method, mild preparation conditions and a controllable preparation time, and has good application prospects in the field of biomedicine.
Inventors:
ZHANG YIQING (CN)
SUN YU (CN)
SUN YU (CN)
Application Number:
PCT/CN2021/091377
Publication Date:
August 18, 2022
Filing Date:
April 30, 2021
Export Citation:
Assignee:
BEIJING GUANGLING MEDICAL TECH CO LTD (CN)
International Classes:
C08J3/075; A61B17/03; A61K9/00; A61K31/77; A61L15/26; A61L31/06; A61P17/02; C08G65/00; C08G65/08; C08J3/24; C08L71/02
Foreign References:
| CN112225912A | 2021-01-15 | |||
| CN111484611A | 2020-08-04 | |||
| US20020064546A1 | 2002-05-30 | |||
| CN111440310A | 2020-07-24 | |||
| CN111440334A | 2020-07-24 |
Other References:
WU XILONG, HE CHAOLIANG, WU YUNDI, CHEN XUESI: "Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 75, 1 January 2016 (2016-01-01), AMSTERDAM, NL , pages 148 - 162, XP055958043, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2015.10.016
KELLY R. STEVENS, JORDAN S. MILLER, BRANDON L. BLAKELY, CHRISTOPHER S. CHEN, SANGEETA N. BHATIA: "Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering : DEGRADABLE HYDROGELS DERIVED FROM PEG-DIACRYLAMIDE", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, JOHN WILEY & SONS, US, vol. 103, no. 10, 1 October 2015 (2015-10-01), US , pages 3331 - 3338, XP055718436, ISSN: 1549-3296, DOI: 10.1002/jbm.a.35478
KELLY R. STEVENS, JORDAN S. MILLER, BRANDON L. BLAKELY, CHRISTOPHER S. CHEN, SANGEETA N. BHATIA: "Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering : DEGRADABLE HYDROGELS DERIVED FROM PEG-DIACRYLAMIDE", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, JOHN WILEY & SONS, US, vol. 103, no. 10, 1 October 2015 (2015-10-01), US , pages 3331 - 3338, XP055718436, ISSN: 1549-3296, DOI: 10.1002/jbm.a.35478
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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