DEHYDRATION SENSORS WITH ION-RESPONSIVE AND CHARGED POLYMERIC SURFACTANTS

WIPO Patent Application WO/2012/023071

A3

A lateral flow assay device for determining the relative ionic strength of urine is described. The device includes a buffering zone having a polyelectrolyte disposed therein, and an indicator zone having a pH indicator non-diffusively immobilized therein, the indicator zone being separate from the buffering zone and positioned adjacent to and in fluid communication with the buffering zone. A detection zone is part of the buffering zone, and has a buffering component comprising a weak polymeric acid and weak polymeric base with a pKa ≤ 10-3, and a class of charged polymeric surfactants that are responsive to relative ion concentrations in a sample solution, and a charged pH indicator with a charge opposite to that of the charged polymeric surfactant. The charged polymeric surfactant is soluble in amounts of greater than or equal to about 1% by weight (≥ 1wt. % solute) in water and aqueous solutions of low ionic concentration of ≤ 0.1 wt. % salts, but insoluble (< 1wt. % solute) in aqueous solution of high ionic concentrations of > 0.1 wt. % salts. The present invention also describes absorbent articles incorporating such an assay device and methods of monitoring dehydration or testing ion strength of a urine sample using such a test format.

SONG XUEDONG (US)
WEI NING (US)
PHILLIPS RONNIE L (US)

PCT/IB2011/053313

June 07, 2012

July 25, 2011

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KIMBERLY CLARK CO (US)
SONG XUEDONG (US)
WEI NING (US)
PHILLIPS RONNIE L (US)

G01N33/493; G01N21/80; G01N31/22; G01N33/52

US20100159599A1	2010-06-24
US20090157024A1	2009-06-18
US5403744A	1995-04-04
US20060137434A1	2006-06-29

See also references of EP 2606350A4

STOKER, Denise, L. et al. (Inc.2300 Winchester Roa, Neenah Wisconsin, US)

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