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Title:
DEHYDROXYLATED FLUORINATING AGENT
Document Type and Number:
WIPO Patent Application WO/2008/001718
Kind Code:
A1
Abstract:
A novel useful dehydroxylated fluorinating agent which comprises sulfuryl fluoride (SO2F2) and an organic base containing no free hydroxy group in the molecule. With the dehydroxylated fluorinating agent, optically active fluorinated derivatives which are important intermediates for medicines and agricultural chemicals, e.g., a 4-fluoroproline derivative, 2'-deoxy-2'-fluorouridine derivative, optically active α-fluorocarboxylic ester derivative, and monofluoromethyl derivative, can be advantageously produced even on a large scale without the need of using any perfluoroalkanesulfonyl fluoride, use of which on a large scale is undesirable.

Inventors:
ISHII AKIHIRO
OOTSUKA TAKASHI
YASUMOTO MANABU
TSURUTA HIDEYUKI
INOMIYA KENJIN
UEDA KOJI
MOGI KAORI
Application Number:
PCT/JP2007/062687
Publication Date:
January 03, 2008
Filing Date:
June 25, 2007
Export Citation:
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Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
OOTSUKA TAKASHI
YASUMOTO MANABU
TSURUTA HIDEYUKI
INOMIYA KENJIN
UEDA KOJI
MOGI KAORI
International Classes:
C07B39/00; C07C17/16; C07C19/08; C07C67/307; C07C69/63; C07D207/16; C07D209/48; C07H19/09; C07B55/00
Domestic Patent References:
WO2004089968A12004-10-21
Foreign References:
JP2006290870A2006-10-26
JPH09507503A1997-07-29
JP2005126386A2005-05-19
JP2006083163A2006-03-30
JP2002531426A2002-09-24
US5760255A1998-06-02
US6248889B12001-06-19
JP2004323518A2004-11-18
JP2005083163A2005-03-31
JP2005336151A2005-12-08
JP2005008534A2005-01-13
Other References:
See also references of EP 2020402A4
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
ORGANIC LETTERS (US, vol. 6, no. 9, 2004, pages 1465 - 1468
TETRAHEDRON LETTERS (UK, vol. 37, no. 1, 1996, pages 17 - 20
FARUMASHIA, vol. 40, no. 2, 2004
SYNTHESIS (GERMANY, vol. 2, 1982, pages 85 - 126
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONGS, INC.
JIKKEN KAGAKU KOZA: "Organic Synthesis IV Acid, Amino acid, Peptide", vol. 22, 1992, MARUZEN, pages: 193 - 309
TETRAHEDRON LETTERS (UNITED KINGDOM, vol. 39, no. 10, 1988, pages 1169 - 1172
CHEM. PHARM. BULL. (JAPAN, vol. 42, no. 3, 1994, pages 595 - 598
KHIM. GETEROTSIKL. SOEDIN. (RUSSIA, vol. 7, 1996, pages 975 - 977
SYNTHETIC COMMUNICATIONS (US, vol. 21, no. 21, 1991, pages 2165 - 2170
Attorney, Agent or Firm:
HASHIMOTO, Takeshi et al. (Ekisaikai Bldg. 1-29, Akashi-cho, Chuo-k, Tokyo 44, JP)
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