Title:
DELIVERY OF DISSOCIATED ISLETS CELLS WITHIN MICROPOROUS ANNEALED PARTICLE SCAFFOLD TO TREAT TYPE 1 DIABETES
Document Type and Number:
WIPO Patent Application WO/2023/183953
Kind Code:
A9
Abstract:
Provided are compositions that include single cell suspensions of pancreatic islet cells, pancreatic islet-like cells derived from iPS cells, or combinations thereof, wherein the cells are present within a MAP scaffold and/or are encapsulated by MAPs. In some embodiments, the MAP scaffold and/the MAPs have a polymer backbone that includes poly(ethyleneglycol) (PEG), hyaluronic acid, polyacrylamide, polymethacrylate, alginate, collagen, or any combination thereof. Also provided are methods for using the presently disclosed compositions for treating Type 1 diabetes, for example by administering to a subject with Type 1 diabetes such a composition via a route and in an amount effective for treating the Type 1 diabetes in the subject. In some embodiments, the administering includes injecting the composition into a kidney capsule, subcutaneously, intraperitoneally, into adipose tissue, intramuscularly, intrahepatically, and/or intrapancreatically into the subject.
Inventors:
GRIFIN DONALD (US)
ROOSA COLLEEN (US)
MA MINGYANG (US)
CHHABRA PREETI (US)
BRAYMAN KENNETH (US)
ROOSA COLLEEN (US)
MA MINGYANG (US)
CHHABRA PREETI (US)
BRAYMAN KENNETH (US)
Application Number:
PCT/US2023/065006
Publication Date:
March 28, 2024
Filing Date:
March 27, 2023
Export Citation:
Assignee:
UNIV VIRGINIA PATENT FOUNDATION (US)
International Classes:
A61K9/16; A61K35/39; A61K47/60; A61L27/48; A61L27/52; A61L27/54; A61L27/56
Attorney, Agent or Firm:
PERKINS, Christopher, P. (US)
Download PDF:
Previous Patent: METHODS AND APPARATUSES FOR NAVIGATING USING A PAIR OF RIGIDIZING DEVICES
Next Patent: AN AQUEOUS ANTIMICROBIAL POLYMER DISPERSION
Next Patent: AN AQUEOUS ANTIMICROBIAL POLYMER DISPERSION