Title:
DELIVERY OF EXOGENOUS COMPOUNDS DELIVERY OF EXOGENOUS COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1996024378
Kind Code:
A3
Abstract:
The invention discloses methods and materials for the utilization of chemically modified oligonucleotides in the treatment of drug-resistant bacterial infections including drug-resistant tuberculosis.
Inventors:
RAPAPORT ELIEZER (US)
METELEV VALERI (US)
ZAMECNIK PAUL C (US)
METELEV VALERI (US)
ZAMECNIK PAUL C (US)
Application Number:
PCT/US1996/001814
Publication Date:
November 14, 1996
Filing Date:
February 09, 1996
Export Citation:
Assignee:
WORCESTER FOUND EX BIOLOGY (US)
RAPAPORT ELIEZER (US)
METELEV VALERI (US)
ZAMECNIK PAUL C (US)
RAPAPORT ELIEZER (US)
METELEV VALERI (US)
ZAMECNIK PAUL C (US)
International Classes:
A61K31/00; A61K31/70; A61K31/7088; A61K38/00; A61K45/00; A61K47/48; A61K48/00; A61P31/00; A61P31/04; A61P31/06; A61P43/00; C12N1/21; (IPC1-7): A61K47/48
Domestic Patent References:
| WO1989007615A1 | 1989-08-24 |
Foreign References:
| CH676247A5 | 1990-12-28 | |||
| EP0305145A2 | 1989-03-01 |
Other References:
ERICHSEN C ET AL: "Effect of N-phosphonacetyl-L-aspartate and D-glucosamine on the incorporation of 5-fluorouridine into normal tissues and an adenocarcinoma in the rat.", ANTICANCER RES, JAN-FEB 1987, VOL. 7, NO. 1, PAGE(S) 77-80, XP000602142
ROSNER A ET AL: "Evaluation of several enrichment procedures for the isolation of recombinant plasmid DNA.", MOL BIOL REP, FEB 15 1979, VOL. 4, NO. 4, PAGE(S) 253-6, NL, XP000602140
HOTTA K ET AL: "PCR inhibition assay for DNA-targeted antibiotics.", J ANTIBIOT, NOV 1995, VOL. 48, NO. 11, PAGE(S) 1267-72, JP, XP002013953
MATSUDA Y ET AL: "Some evidence for interaction of D-cycloserine with DNA.", J ANTIBIOT, JUL 1982, VOL. 35, NO. 7, PAGE(S) 893-9, JP, XP002013954
RAPAPORT E ET AL: "Antimycobacterial activities of antisense oligodeoxynucleotide phosphorothioates in drug-resistant strains.", PROC NATL ACAD SCI U S A,, VOL. 93, NO. 2, PAGE(S) 709-13, 23 January 1996 (1996-01-23), XP002013955
R. BERKOW ET AL. (EDITORS): "The Merck Manual of Diagnosis and Therapy", 1987, MERCK & CO, RAHWAY, US, XP002013956
ROSNER A ET AL: "Evaluation of several enrichment procedures for the isolation of recombinant plasmid DNA.", MOL BIOL REP, FEB 15 1979, VOL. 4, NO. 4, PAGE(S) 253-6, NL, XP000602140
HOTTA K ET AL: "PCR inhibition assay for DNA-targeted antibiotics.", J ANTIBIOT, NOV 1995, VOL. 48, NO. 11, PAGE(S) 1267-72, JP, XP002013953
MATSUDA Y ET AL: "Some evidence for interaction of D-cycloserine with DNA.", J ANTIBIOT, JUL 1982, VOL. 35, NO. 7, PAGE(S) 893-9, JP, XP002013954
RAPAPORT E ET AL: "Antimycobacterial activities of antisense oligodeoxynucleotide phosphorothioates in drug-resistant strains.", PROC NATL ACAD SCI U S A,, VOL. 93, NO. 2, PAGE(S) 709-13, 23 January 1996 (1996-01-23), XP002013955
R. BERKOW ET AL. (EDITORS): "The Merck Manual of Diagnosis and Therapy", 1987, MERCK & CO, RAHWAY, US, XP002013956
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