Title:
DELIVERY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS THROUGH AN INHALATION ROUTE
Document Type and Number:
WIPO Patent Application WO2002094246
Kind Code:
A3
Abstract:
The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an NSAID. In a method aspect of the present invention, an NSAID is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an NSAID, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an NSAID; and, b) a device that forms an NSAID aerosol from the composition, for inhalation by the mammal.
Inventors:
RABINOWITZ JOSHUA D
ZAFFARONI ALEJANDRO C
ZAFFARONI ALEJANDRO C
Application Number:
PCT/US2002/016558
Publication Date:
January 16, 2003
Filing Date:
May 23, 2002
Export Citation:
Assignee:
ALEXZA MOLECULAR DELIVERY CORP (US)
International Classes:
A61K9/00; A61K9/12; A61K31/137; A61K31/138; A61K31/165; A61K31/192; A61K31/216; A61K31/27; A61K31/404; A61K31/405; A61K31/407; A61K31/4196; A61K31/422; A61K31/423; A61K31/473; A61K31/49; A61K31/5517; F24V30/00; (IPC1-7): A61K9/72; A61K31/405
Domestic Patent References:
| WO2000027363A1 | 2000-05-18 | |||
| WO2002024158A2 | 2002-03-28 |
Foreign References:
| EP0606486A1 | 1994-07-20 | |||
| US5993805A | 1999-11-30 | |||
| US6051566A | 2000-04-18 |
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