Title:
DELIVERY OF SMALL HYDROPHILIC MOLECULES PACKAGED INTO LIPID VESICLES
Document Type and Number:
WIPO Patent Application WO2003000233
Kind Code:
A3
Abstract:
Means and methods are provided for the generation and use of delivery vehicles for small molecules. In one aspect of the invention lipid vesicles comprising proteinaceous channel and said small molecules are generated. Said proteinaceous channel and/or said lipid vesicle are formulated such that said small molecule is released in the vicinity of a target cell. Said target cell may be present in vitro or in vivo.
Inventors:
FRIESEN ROBERT HEINZ EDWARD (NL)
POOLMAN BEREND (NL)
FERINGA BERNARDM LUCAS (NL)
ENGBERTS JAN BERNARD FREDERIK (NL)
POOLMAN BEREND (NL)
FERINGA BERNARDM LUCAS (NL)
ENGBERTS JAN BERNARD FREDERIK (NL)
Application Number:
PCT/NL2002/000412
Publication Date:
October 16, 2003
Filing Date:
June 21, 2002
Export Citation:
Assignee:
APPLIED NANOSYSTEMS BV (NL)
FRIESEN ROBERT HEINZ EDWARD (NL)
POOLMAN BEREND (NL)
FERINGA BERNARDM LUCAS (NL)
ENGBERTS JAN BERNARD FREDERIK (NL)
FRIESEN ROBERT HEINZ EDWARD (NL)
POOLMAN BEREND (NL)
FERINGA BERNARDM LUCAS (NL)
ENGBERTS JAN BERNARD FREDERIK (NL)
International Classes:
A61K9/127; (IPC1-7): A61K9/127
Domestic Patent References:
| WO1999020252A1 | 1999-04-29 |
Foreign References:
| US5820879A | 1998-10-13 |
Other References:
SIMOES S ET AL.: "Enhancement of cationic liposome-mediated gene delivery by transferrin and fusogenic peptides", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, vol. 24, 15 June 1997 (1997-06-15) - 19 June 1997 (1997-06-19), pages 659 - 660, XP002098090, ISSN: 1022-0178
HÄSE CC ET AL.: "Purification and functional reconstitution of the recombinant large mechanosensitive ion channel (MscL) of Escherichia coli.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 31, 1995, pages 18329 - 18334, XP002131093, ISSN: 0021-9258
HÄSE CC ET AL.: "Molecular dissection of the large mechanosensitive ion channel (MscL) of E. coli: Mutants with altered channel gating and pressure sensitivity.", JOURNAL OF MEMBRANE BIOLOGY, vol. 157, no. 1, 1997, pages 17 - 25, XP002183679, ISSN: 0022-2631
MARTINAC B: "Mechanosensitive channels in prokaryotes.", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 11, no. 2, 2001, pages 61 - 76, XP002183680, ISSN: 1015-8987
HÄSE CC ET AL.: "Purification and functional reconstitution of the recombinant large mechanosensitive ion channel (MscL) of Escherichia coli.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 31, 1995, pages 18329 - 18334, XP002131093, ISSN: 0021-9258
HÄSE CC ET AL.: "Molecular dissection of the large mechanosensitive ion channel (MscL) of E. coli: Mutants with altered channel gating and pressure sensitivity.", JOURNAL OF MEMBRANE BIOLOGY, vol. 157, no. 1, 1997, pages 17 - 25, XP002183679, ISSN: 0022-2631
MARTINAC B: "Mechanosensitive channels in prokaryotes.", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 11, no. 2, 2001, pages 61 - 76, XP002183680, ISSN: 1015-8987
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