Title:
DELTA CLEAVAGE PRODUCTS AND METHODS BASED THEREON
Document Type and Number:
WIPO Patent Application WO2000002897
Kind Code:
A9
Abstract:
The present invention is directed to a Delta cleavage peptide and fragments, derivative and analogs thereof, and its encoding nucleic acids. The present invention is also directed to a soluble Delta peptide and fragments, derivative and analogs thereof, and its encoding nucleic acids. The present invention is also directed to protein complexes of Delta and Kuz. The present invention is also directed to methods for detecting or measuring Delta activation by observing or measuring Delta cleavage products that are indicative of Delta activation. The present invention is also directed to methods for detecting or measuring Kuz activation by observing or measuring Delta cleavage products that are indicative of Kuz activation. The present invention is also directed to methods for detecting a molecule that modulates Delta activation or Kuz function by observing or measuring a change in the amount of or pattern of Delta cleavage products. The present invention is based, at least in part, on the discovery that Delta in its active form, i.e., the form that mediates signal transduction and that binds Notch, is a soluble fragment consisting of the extracellular domain.
Inventors:
ARTAVANIS-TSAKONAS SPYRIDON
RAND MATTHEW D
QI HUILIN
RAND MATTHEW D
QI HUILIN
Application Number:
PCT/US1999/015817
Publication Date:
July 20, 2000
Filing Date:
July 13, 1999
Export Citation:
Assignee:
UNIV YALE (US)
International Classes:
A01K67/027; A61K31/711; A61K38/00; A61K39/395; A61K48/00; A61P25/00; A61P35/00; C07K14/47; C07K14/705; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): A61K38/00; A01N37/18; A01N43/04; A61K31/70; C07H21/04; C07K5/00; C07K7/00; C07K16/00; C07K17/00; C12P21/06; C12P21/08; G01N33/48; G01N33/53; G01N33/574
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