DEMAND-RELEASE BIOACTIVE COMPOSITION FOR IMPLANTABLE MEDICAL DEVICES

Title:

DEMAND-RELEASE BIOACTIVE COMPOSITION FOR IMPLANTABLE MEDICAL DEVICES

Document Type and Number:

WIPO Patent Application WO2004080339

Kind Code:

A3

Abstract:

A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.

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Inventors:

STOKES KENNETH B (US)
HOBOT CHRISTOPHER M (US)
EBERT MICHAEL J (US)

Application Number:

PCT/US2004/006885

Publication Date:

August 18, 2005

Filing Date:

March 08, 2004

Export Citation:

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Assignee:

MEDTRONIC INC (US)
STOKES KENNETH B (US)
HOBOT CHRISTOPHER M (US)
EBERT MICHAEL J (US)

International Classes:

A61L27/54; A61L31/16; A61N1/05; (IPC1-7): A61L31/16; A61N1/05; A61L27/54

Foreign References:

US5877263A	1999-03-02
US5589563A	1996-12-31
US20030204229A1	2003-10-30
US4506680A	1985-03-26
US4577642A	1986-03-25
US4606118A	1986-08-19
EP0791372A1	1997-08-27

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