Title:
DEMENTIA THERAPEUTIC AGENT COMBINING PYRAZOLOQUINOLINE DERIVATIVE AND MEMANTINE
Document Type and Number:
WIPO Patent Application WO/2018/221550
Kind Code:
A1
Abstract:
Provided is a therapeutic agent for Alzheimer's disease. The therapeutic agent combines: (I) (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-pyrazolo[4,3-c]quinolin-4(5H)-one, which is represented by formula (I), or a pharmaceutically acceptable salt thereof; and (II) memantine, which is represented by formula (II), or a pharmaceutically acceptable salt thereof.
More Like This:
Inventors:
MIYAMOTO MAI (JP)
KOTANI SADAHARU (JP)
KOTANI SADAHARU (JP)
Application Number:
PCT/JP2018/020649
Publication Date:
December 06, 2018
Filing Date:
May 30, 2018
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K31/4745; A61K31/13; A61P25/28; A61P43/00
Domestic Patent References:
| WO2014163147A1 | 2014-10-09 | |||
| WO2013051639A1 | 2013-04-11 |
Foreign References:
| JP2012515761A | 2012-07-12 | |||
| US8563565B2 | 2013-10-22 |
Other References:
MECOCCI ET AL., INT J GERIATR PSYCHIATRY, vol. 24, pages 532
GROSSBERG ET AL., DEMENT GERIATR COGN DISORD, vol. 27, 2009, pages 164
HOMMA ET AL., DEMENT. GERIATR. COGN. DISORD., vol. 11, 2000, pages 299
HOMMA ET AL., DEMENT. GERIATR. COGN. DISORD., vol. 25, 2008, pages 399
MORI ET AL., ANN. NEUROL, vol. 72, 2012, pages 41
HOLMES, NEUROLOGY, vol. 63, 2004, pages 214
GAUTHIER ET AL., INT PSYCHOGERIATR, vol. 14, 2002, pages 389
RASKIND ET AL., NEUROLOGY, vol. 54, 2000, pages 226
WMBLAD ET AL., NEUROLOGY, vol. 69, 2007, pages S14
LOPEZ ET AL., J NEUROL NEUROSURG PSYCHIATRY, vol. 80, 2009, pages 600
HOWARD ET AL., NEW ENG J. MED, vol. 366, 2012, pages 893
WHITEHOUSE ET AL., SCIENCE, vol. 215, 1982, pages 1237
SNYDER ET AL., ALZHEIMER'S & DEMENTIA, vol. 1, 2005, pages 126 - 135
SAMBETH ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 572, 2007, pages 151 - 159
See also references of EP 3632437A4
GROSSBERG ET AL., DEMENT GERIATR COGN DISORD, vol. 27, 2009, pages 164
HOMMA ET AL., DEMENT. GERIATR. COGN. DISORD., vol. 11, 2000, pages 299
HOMMA ET AL., DEMENT. GERIATR. COGN. DISORD., vol. 25, 2008, pages 399
MORI ET AL., ANN. NEUROL, vol. 72, 2012, pages 41
HOLMES, NEUROLOGY, vol. 63, 2004, pages 214
GAUTHIER ET AL., INT PSYCHOGERIATR, vol. 14, 2002, pages 389
RASKIND ET AL., NEUROLOGY, vol. 54, 2000, pages 226
WMBLAD ET AL., NEUROLOGY, vol. 69, 2007, pages S14
LOPEZ ET AL., J NEUROL NEUROSURG PSYCHIATRY, vol. 80, 2009, pages 600
HOWARD ET AL., NEW ENG J. MED, vol. 366, 2012, pages 893
WHITEHOUSE ET AL., SCIENCE, vol. 215, 1982, pages 1237
SNYDER ET AL., ALZHEIMER'S & DEMENTIA, vol. 1, 2005, pages 126 - 135
SAMBETH ET AL., EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 572, 2007, pages 151 - 159
See also references of EP 3632437A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF:
Previous Patent: TERMINAL DEVICE AND BASE STATION DEVICE
Next Patent: LEWY BODY DISEASE THERAPEUTIC AGENT CONTAINING PYRAZOLOQUINOLINE DERIVATIVE
Next Patent: LEWY BODY DISEASE THERAPEUTIC AGENT CONTAINING PYRAZOLOQUINOLINE DERIVATIVE