Title:
DEMETHYLIVABRADINE SALT, AND PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/106636
Kind Code:
A1
Abstract:
A demethylivabradine salt, and a preparation method therefor and uses thereof. The demethylivabradine salt is a pharmaceutically acceptable salt, and the pharmaceutically acceptable salt comprises citrate, hydrobromide, sulfate, phosphate, acetate, trifluoroacetate, lactate, acetonate, malonate, succinate, glutarate, fumarate, tartrate, maleate, ascorbate, oxalate, mesylate, benzene sulfonate and camphorate.
Inventors:
WANG ZHIGANG (CN)
LOU HONGXIANG (CN)
LI WENBAO (CN)
MA ENLONG (CN)
LOU HONGXIANG (CN)
LI WENBAO (CN)
MA ENLONG (CN)
Application Number:
PCT/CN2015/000026
Publication Date:
July 23, 2015
Filing Date:
January 16, 2015
Export Citation:
Assignee:
SHANDONG CHENGCHUANG PHARMACEUTICAL R & D CO LTD (CN)
International Classes:
C07D223/16; A61K9/20; A61K9/48; A61K31/55; A61P9/06; A61P9/10; C07C51/41; C07C57/145; C07C57/15; C07C59/255; C07C59/265
Foreign References:
| CN101851205A | 2010-10-06 | |||
| EP0534859A1 | 1993-03-31 | |||
| CN103724266A | 2014-04-16 |
Other References:
LI, NA ET AL.: "Determination and Ivabradine and Its Active Metabolite N-desmethylivabradine in Rat Plasma by HPLC and Their Pharmacokinetic Study", CHINESE PHARMACEUTICAL JOURNAL, vol. 46, no. 15, 31 August 2011 (2011-08-31), pages 1195 - 1199
Attorney, Agent or Firm:
JINAN SHUNYUAN PATENT AGENCY CO., LTD. (CN)
济南舜源专利事务所有限公司 (CN)
济南舜源专利事务所有限公司 (CN)
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