Title:
DENDRITIC CELL-MIMETIC FUNCTIONAL NANOSTRUCTURE COMPRISING αPD-1, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/113545
Kind Code:
A1
Abstract:
The present invention relates to a dendritic cell-mimetic nanostructure for inhibiting immune checkpoints, and a preparation method therefor, the nanostructure comprising a nanoparticle core and a shell, which comprises the cell membrane of a lipid molecule derived from dendritic cells, wherein the shell comprises αPD-1 monoclonal antibody, and the strong activation of cytotoxic T cells, caused by immune checkpoint inhibitory activity, increases an immune response, and thus an excellent cancer immunotherapy effect can be provided.
Inventors:
HA SANG-JUN (KR)
MOON CHAE-WON (KR)
KIM DA-HAE (KR)
HONG JINKEE (KR)
KIM TAIHYUN (KR)
LEE YOOJIN (KR)
MOON CHAE-WON (KR)
KIM DA-HAE (KR)
HONG JINKEE (KR)
KIM TAIHYUN (KR)
LEE YOOJIN (KR)
Application Number:
PCT/KR2022/020602
Publication Date:
June 22, 2023
Filing Date:
December 16, 2022
Export Citation:
Assignee:
FORTUGA BIO INC (KR)
International Classes:
A61K9/51; A61K39/00; A61K47/54; A61P35/00; C07K16/28
Foreign References:
| KR20210084552A | 2021-07-07 | |||
| JP2020073617A | 2020-05-14 | |||
| KR20220080681A | 2022-06-14 |
Other References:
LE QUOC-VIET, LEE JAIWOO, LEE HOBIN, SHIM GAYONG, OH YU-KYOUNG: "Cell membrane-derived vesicles for delivery of therapeutic agents", ACTA PHARMACEUTICA SINICA B, vol. 11, no. 8, 1 August 2021 (2021-08-01), pages 2096 - 2113, XP093072133, ISSN: 2211-3835, DOI: 10.1016/j.apsb.2021.01.020
LUO BAOHONG, ZHAN YIKANG, LUO MINQI, DONG HUIMIN, LIU JUN, LIN YINGTONG, ZHANG JUNSONG, WANG GUANWEN, VERHOEYEN ELS, ZHANG YIWEN, : "Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration", CELL DEATH & DISEASE, vol. 11, no. 11, 12 November 2020 (2020-11-12), pages 973, XP093072136, DOI: 10.1038/s41419-020-03187-1
GONG PING, WANG YIFAN, ZHANG PENGFEI, YANG ZHAOGANG, DENG WEIYE, SUN ZHIHONG, YANG MINGMING, LI XUEFENG, MA GONGCHENG, DENG GUANJU: "Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy", CANCERS, vol. 13, no. 1, 30 December 2020 (2020-12-30), pages 77, XP093072160, DOI: 10.3390/cancers13010077
LUO BAOHONG, ZHAN YIKANG, LUO MINQI, DONG HUIMIN, LIU JUN, LIN YINGTONG, ZHANG JUNSONG, WANG GUANWEN, VERHOEYEN ELS, ZHANG YIWEN, : "Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration", CELL DEATH & DISEASE, vol. 11, no. 11, 12 November 2020 (2020-11-12), pages 973, XP093072136, DOI: 10.1038/s41419-020-03187-1
GONG PING, WANG YIFAN, ZHANG PENGFEI, YANG ZHAOGANG, DENG WEIYE, SUN ZHIHONG, YANG MINGMING, LI XUEFENG, MA GONGCHENG, DENG GUANJU: "Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy", CANCERS, vol. 13, no. 1, 30 December 2020 (2020-12-30), pages 77, XP093072160, DOI: 10.3390/cancers13010077
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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