Title:
DENDRITIC CELL OBTAINED BY ANTIGEN PULSING
Document Type and Number:
WIPO Patent Application WO/2005/100547
Kind Code:
A1
Abstract:
Dendritic cells effective in the prevention and curing of diseases, especially hepatitis B. Dendritic cells having HBs antigen presenting capability obtained by a process including the step of pulsing dendritic cells with HBs antigen are effective as a dendritic cell vaccine in the prevention and curing of hepatitis B. As the HBs antigen, use can be made of an HBs antigen contained in HB vaccine. Vaccine pulsed dendritic cells obtained by a process including the step of pulsing dendritic cells with a vaccine can be used as a dendritic cell vaccine in not only patients but also healthy subjects. As the vaccine for pulsing, use can be made of a wide variety of vaccines.
Inventors:
ONJI MORIKAZU
AKBAR SK MD FAZLE
AKBAR SK MD FAZLE
Application Number:
PCT/JP2004/013321
Publication Date:
October 27, 2005
Filing Date:
September 13, 2004
Export Citation:
Assignee:
TECHNO NETWORK SHIKOKU CO LTD (JP)
ONJI MORIKAZU
AKBAR SK MD FAZLE
ONJI MORIKAZU
AKBAR SK MD FAZLE
International Classes:
A61K35/12; A61K35/14; A61K35/15; A61K39/29; A61P1/16; A61P31/12; A61P31/20; A61P37/04; A61P43/00; C12N5/07; C12N5/0784; C12N5/0786; (IPC1-7): C12N5/06; C12N5/08; A61K35/14; A61P31/12
Other References:
AKBAR S.M. ET AL: "Production, therapeutic effect and mechanism of action of a vaccine containing antigen-pulsed denditric cells for treatment of chronic hepatitis B virus infection.", HEPATOLOGY., vol. 36, no. 4, 2002, pages 301A, XP002904147
ONJI M. ET AL: "Virus-sei Kan'en no Byotai Keisei ni Okeru Jojo Saibo no Yakawaru.", vol. 35, no. 8, 2003, pages 1833 - 1839, XP002994484
STOBER D. ET AL: "Dendritic cell pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MCH class I-restricted cytotoxic T cells.", EUR J IMMUNOL., vol. 32, no. 4, 2002, pages 1099 - 1108, XP002904148
ONJI M. ET AL: "Jijo Saibo Kanshikkan no Men'eki Byotai Oyobi Chiryo.", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY., vol. 27, no. 2, 30 April 2004 (2004-04-30), pages 64 - 76, XP002994485
ONJI M. ET AL: "Jujo Saibo to Kanshikkan no Chiryo.", MINOPHAGEN MEDICAL REVIEW., vol. 49, no. 3, 20 May 2004 (2004-05-20), pages 163 - 170, XP002994486
BOCHER W.O. ET EL: "Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.", EUR J IMMUNOL., vol. 31, no. 7, 2001, pages 2071 - 2079, XP002904149
ONJI M. ET AL: "Virus-sei Kan'en no Byotai Keisei ni Okeru Jojo Saibo no Yakawaru.", vol. 35, no. 8, 2003, pages 1833 - 1839, XP002994484
STOBER D. ET AL: "Dendritic cell pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MCH class I-restricted cytotoxic T cells.", EUR J IMMUNOL., vol. 32, no. 4, 2002, pages 1099 - 1108, XP002904148
ONJI M. ET AL: "Jijo Saibo Kanshikkan no Men'eki Byotai Oyobi Chiryo.", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY., vol. 27, no. 2, 30 April 2004 (2004-04-30), pages 64 - 76, XP002994485
ONJI M. ET AL: "Jujo Saibo to Kanshikkan no Chiryo.", MINOPHAGEN MEDICAL REVIEW., vol. 49, no. 3, 20 May 2004 (2004-05-20), pages 163 - 170, XP002994486
BOCHER W.O. ET EL: "Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.", EUR J IMMUNOL., vol. 31, no. 7, 2001, pages 2071 - 2079, XP002904149
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (OAP TOWER 8-30, Tenmabashi 1-chome, Kita-ku, Osaka-sh, Osaka 26, JP)
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