Title:
DENDRITIC CHELATED COMPOUNDS, METHODS FOR MAKING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2008/043911
Kind Code:
A3
Abstract:
The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present invention have the following formula (I): [[MC]-En-[D]m-X1p1X2p2X3p3 X4p4]z
- z B+ (I), where m is a magnetic or scintigraphic marker, C is a chelating agent of the marker M, E is a spacer, n = 0 or 1, D is compound capable of forming a dendritic structure, m is an integer equal to 1 or 2 or 4, X1 is a group increasing the complex lipophily, p1 is an integer from 0 to 12, X2 is a group increasing the complex specificity for a particular organ, p2 is an integer equal to 1 or 2 or 4, X3 is a group having a therapeutic activity, p3 is an integer equal to 0, 1, 2 or 4, X4 is a CH3 group, p4 is an integer from 0 to 12, B is a counter-ion, z is an integer equal to 0, 1, 2, 3 or 4. The invention can be used in the field of pharmacy, more precisely in medical imaging.
Inventors:
FELDER-FLESCH DELPHINE (FR)
STEIBEL JÉRÔME (FR)
BERTIN ANNABELLE (FR)
STEIBEL JÉRÔME (FR)
BERTIN ANNABELLE (FR)
Application Number:
PCT/FR2007/001645
Publication Date:
December 18, 2014
Filing Date:
October 09, 2007
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV PASTEUR (FR)
FELDER-FLESCH DELPHINE (FR)
STEIBEL JÉRÔME (FR)
BERTIN ANNABELLE (FR)
UNIV PASTEUR (FR)
FELDER-FLESCH DELPHINE (FR)
STEIBEL JÉRÔME (FR)
BERTIN ANNABELLE (FR)
International Classes:
A61K49/10; A61K31/166; A61K31/216; A61K31/4709; A61K49/12; A61P25/28; C07C225/06; C07C233/18; C07C237/08; C07D215/26; C07F9/02; C07F11/00; C07F13/00; C08F8/42; C08G83/00
Domestic Patent References:
| WO2006033766A2 | 2006-03-30 | |||
| WO2006088958A2 | 2006-08-24 |
Foreign References:
| US20060165601A1 | 2006-07-27 | |||
| FR2867473A1 | 2005-09-16 | |||
| FR2883562A1 | 2006-09-29 | |||
| US6982324B1 | 2006-01-03 |
Other References:
WIENER E C ET AL: "DENDRIMER-BASED METAL CHELATES: A NEW CLASS OF MAGNETIC RESONANCE IMAGING CONTRAST AGENTS", MAGNETIC RESONANCE IN MEDICINE, ACADEMIC PRESS, DULUTH, MN, US, vol. 31, no. 1, January 1994 (1994-01-01), pages 1 - 8, XP000423671, ISSN: 0740-3194
D. IMBERT ET AL: "Synthesis and iron(III) complexing ability of CacCAM, a new analog of enterobactin possessing a free carboxylic anchor arm. Comparative studies with TRENCAM", NEW J. CHEM., vol. 24, 2000, pages 281 - 288, XP002437468
THOMAS F ET AL: "Partition Coefficients (Free Ligands and their Iron(III) Complexes) and Lipophilic Behavior of New Abiotic Chelators. Correlation to Biological Activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 20, 18 October 1999 (1999-10-18), pages 3035 - 3040, XP004180533, ISSN: 0960-894X
D. IMBERT ET AL: "Synthesis and iron(III) complexing ability of CacCAM, a new analog of enterobactin possessing a free carboxylic anchor arm. Comparative studies with TRENCAM", NEW J. CHEM., vol. 24, 2000, pages 281 - 288, XP002437468
THOMAS F ET AL: "Partition Coefficients (Free Ligands and their Iron(III) Complexes) and Lipophilic Behavior of New Abiotic Chelators. Correlation to Biological Activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 20, 18 October 1999 (1999-10-18), pages 3035 - 3040, XP004180533, ISSN: 0960-894X
Attorney, Agent or Firm:
NOËL, Chantal et al. (36 rue de Saint-Pétersbourg, Paris, FR)
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