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Title:
DENDRON-LIKE LIPID COMPOUND, LIPOSOME, LIPID COMPLEX, AND LIPID NANOPARTICLE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/236824
Kind Code:
A1
Abstract:
The present application provides a dendron-like lipid compound, a liposome, a lipid complex, and a lipid nanoparticle and a use thereof. The dendron-like lipid compound is selected from any one of structures represented by formulas I-III. The present application provides a series of dendron-like lipid compounds of novel structures; and liposomes prepared from the lipid compounds provided by the present application have uniform particle size distribution, carry negative charges on the surfaces, and have low cytotoxicity. The lipid nanoparticle provided by the present application can specifically target and deliver active substances to cells, tissues or organs, thereby realizing targeted delivery of the active substances.

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Inventors:
WU LINPING (CN)
HE GUANTAO (CN)
HUANG FUJIAN (CN)
Application Number:
PCT/CN2023/097308
Publication Date:
December 14, 2023
Filing Date:
May 31, 2023
Export Citation:
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Assignee:
GUANGZHOU INST BIOMED & HEALTH (CN)
International Classes:
C07D249/04; A61K9/127; A61K31/16; A61K45/00; A61K47/18; C07C233/05
Domestic Patent References:
WO2019147338A22019-08-01
Foreign References:
CN101616677A2009-12-30
CN112823149A2021-05-18
CN114539083A2022-05-27
CN112823029A2021-05-18
CN104107432A2014-10-22
CN105056251A2015-11-18
US20200283482A12020-09-10
Other References:
YAGI NOBUHIRO, OGAWA YOSHIKATSU, KODAKA MASATO, OKADA TOMOKO, TOMOHIRO TAKENORI, OKUNO HIROAKI, KONAKAHARA TAKEO: "A surface-modified functional liposome capable of binding to cell membranes", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, no. 17, 1 January 1999 (1999-01-01), UK , pages 1687 - 1688, XP093114054, ISSN: 1359-7345, DOI: 10.1039/a905322k
OGAWA, Y. ET AL.: "Synthesis of a Novel Lipopeptide with α-Melanocyte-Stimulating Hormone Peptide Ligand and Its Effect on Liposome Stability", LIPIDS, vol. 34, no. 4, 31 December 1999 (1999-12-31), XP009142868
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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