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Title:
DENGUE VACCINE ANTIGEN INDUCING NEUTRALIZING ANTIBODY BUT INHIBITING INDUCTION OF INFECTION-ENHANCING ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2017/179726
Kind Code:
A1
Abstract:
A dengue vaccine antigen, which induces a neutralizing antibody but inhibits the induction of an infection-enhancing antibody, characterized by containing an envelope protein having a mutation at the 107th or 87th amino acid in the amino acid sequence of dengue virus envelope protein. The dengue vaccine antigen according to the present invention induces a neutralizing antibody but does not inhibit the induction of an infection-enhancing antibody. Thus, the dengue vaccine antigen is expected to exhibit high preventive efficacy even at a low vaccine dose and be appropriately usable for treating or preventing dengue fever or dengue hemorrhagic fever at high safety.

Inventors:
KONISHI EIJI (JP)
YAMANAKA ATSUSHI (JP)
RAMASOOTA PONGRAMA (TH)
PITAKSAJJAKUL PANNAMTHIP (TH)
Application Number:
JP2017/015384
Publication Date:
October 19, 2017
Filing Date:
April 14, 2017
Export Citation:
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Assignee:
UNIV OSAKA (JP)
MAHIDOL UNIV (TH)
International Classes:
C12N15/09; A61K39/12; A61P31/12; C07K14/18
Foreign References:
Other References:
CRILL,W.D. ET AL.: "Sculpting humoral immunity through dengue vaccination to enhance protective immunity", FRONTIERS IN IMMUNOLOGY, vol. 3, 2012, pages 1 - 19, XP055199219, DOI: doi:10.3389/fimmu.2012.00334
HUGHES,H.R. ET AL.: "Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement", VIROLOGY JOURNAL, vol. 9, no. 1, 2012, pages 115, XP021133341, DOI: doi:10.1186/1743-422X-9-115
DATABASE Nucleotide [online] 28 November 2001 (2001-11-28), "Dengue virus type 1 genomic RNA, complete genome, strain:Mochizuki", XP055601560, retrieved from NCBI Database accession no. AB074760
ZULKARNAIN,E. ET AL.: "Molecular Comparison of Dengue Type 1 Mochizuki Strain Virus and Other Selected Viruses Concerning Nucleotide and Amino Acid Sequences of Genomic RNA: A Consideration of Viral Epidemiology and Variation", MICROBIOLOGY AND IMMUNOLOGY, vol. 38, no. 7, 1994, pages 581 - 585, XP055601570
TANG,C.T. ET AL.: "An Epitope-Substituted DNA Vaccine Improves Safety and Immunogenicity against Dengue Virus Type 2", PLOS NEGLECTED TROPICAL DISEASES, vol. 9, no. 7, 2015, pages e0003903, XP055601575
YAMANAKA,A. ET AL.: "A Mouse Monoclonal Antibody against Dengue Virus Type 1 Mochizuki Strain Targeting Envelope Protein Domain II and Displaying Strongly Neutralizing but Not Enhancing Activity", JOURNAL OF VIROLOGY, vol. 87, no. 23, 2013, pages 12828 - 12837, XP055601589
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
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