Title:
DENGUE-VIRUS SEROTYPE NEUTRALIZING ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2013/035345
Kind Code:
A3
Abstract:
Materials and methods are provided for treating dengue infections. Human monoclonal antibodies against all serotypes of dengue virus are also provided. Methods of using human monoclonal antibodies to neutralize all dengue-virus serotypes are provided using patients' peripheral blood lymphocytes.
Inventors:
SETTHAPRAMOTE CHAYANEE (TH)
SASAKI TADAHIRO (JP)
KUHARA MOTOKI (JP)
RAMASOOTA PONGRAMA (TH)
THATTIYAPHONG AREE (TH)
ANANTAPREECHA SURAPEE (TH)
SAWANPANYALERT PATHOM (TH)
OKUNO YOSHINOBU (JP)
IKUTA KAZUYOSHI (JP)
A-NUEGOONPIPAT ATCHAREEYA (TH)
DHEPAKSON PANADDA (TH)
PRACHASUPHAP APICHAI (TH)
SASAKI TADAHIRO (JP)
KUHARA MOTOKI (JP)
RAMASOOTA PONGRAMA (TH)
THATTIYAPHONG AREE (TH)
ANANTAPREECHA SURAPEE (TH)
SAWANPANYALERT PATHOM (TH)
OKUNO YOSHINOBU (JP)
IKUTA KAZUYOSHI (JP)
A-NUEGOONPIPAT ATCHAREEYA (TH)
DHEPAKSON PANADDA (TH)
PRACHASUPHAP APICHAI (TH)
Application Number:
PCT/JP2012/005699
Publication Date:
September 06, 2013
Filing Date:
September 07, 2012
Export Citation:
Assignee:
UNIV OSAKA (JP)
UNIV OSAKA RES FOUND (JP)
MEDICAL & BIOL LAB CO LTD (JP)
UNIV MAHIDOL (TH)
DEPT OF MEDICAL SCIENCES DMSC (TH)
SETTHAPRAMOTE CHAYANEE (TH)
SASAKI TADAHIRO (JP)
KUHARA MOTOKI (JP)
RAMASOOTA PONGRAMA (TH)
THATTIYAPHONG AREE (TH)
ANANTAPREECHA SURAPEE (TH)
SAWANPANYALERT PATHOM (TH)
OKUNO YOSHINOBU (JP)
IKUTA KAZUYOSHI (JP)
A-NUEGOONPIPAT ATCHAREEYA (TH)
DHEPAKSON PANADDA (TH)
PRACHASUPHAP APICHAI (TH)
UNIV OSAKA RES FOUND (JP)
MEDICAL & BIOL LAB CO LTD (JP)
UNIV MAHIDOL (TH)
DEPT OF MEDICAL SCIENCES DMSC (TH)
SETTHAPRAMOTE CHAYANEE (TH)
SASAKI TADAHIRO (JP)
KUHARA MOTOKI (JP)
RAMASOOTA PONGRAMA (TH)
THATTIYAPHONG AREE (TH)
ANANTAPREECHA SURAPEE (TH)
SAWANPANYALERT PATHOM (TH)
OKUNO YOSHINOBU (JP)
IKUTA KAZUYOSHI (JP)
A-NUEGOONPIPAT ATCHAREEYA (TH)
DHEPAKSON PANADDA (TH)
PRACHASUPHAP APICHAI (TH)
International Classes:
C07K16/10
Domestic Patent References:
| WO2010043977A2 | 2010-04-22 | |||
| WO2010093335A1 | 2010-08-19 | |||
| WO2004076677A2 | 2004-09-10 | |||
| WO2010073647A1 | 2010-07-01 | |||
| WO2009011941A2 | 2009-01-22 |
Foreign References:
| EP2009094A1 | 2008-12-31 |
Other References:
KUBOTA-KOKETSU R ET AL: "Broad neutralizing human monoclonal antibodies against influenza virus from vaccinated healthy donors", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 387, no. 1, 11 September 2009 (2009-09-11), pages 180 - 185, XP026378974, ISSN: 0006-291X, [retrieved on 20090704], DOI: 10.1016/J.BBRC.2009.06.151
A. K. I. FALCONAR: "Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins", ARCHIVES OF VIROLOGY, vol. 144, no. 12, 16 December 1999 (1999-12-16), pages 2313 - 2330, XP055052767, ISSN: 0304-8608, DOI: 10.1007/s007050050646
CHAYANEE SETTHAPRAMOTE ET AL: "Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 423, no. 4, 13 July 2012 (2012-07-13), pages 867 - 872, XP028427449, ISSN: 0006-291X, [retrieved on 20120617], DOI: 10.1016/J.BBRC.2012.06.057
A. K. I. FALCONAR: "Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins", ARCHIVES OF VIROLOGY, vol. 144, no. 12, 16 December 1999 (1999-12-16), pages 2313 - 2330, XP055052767, ISSN: 0304-8608, DOI: 10.1007/s007050050646
CHAYANEE SETTHAPRAMOTE ET AL: "Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 423, no. 4, 13 July 2012 (2012-07-13), pages 867 - 872, XP028427449, ISSN: 0006-291X, [retrieved on 20120617], DOI: 10.1016/J.BBRC.2012.06.057
Attorney, Agent or Firm:
SHOJI, Takashi et al. (5-6-13 Nishinakajima, Yodogawa-ku, Osaka-sh, Osaka 11, JP)
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