Title:
DEPLETION OF HOST CELL COMPONENTS FROM LIVE VIRUS VACCINES
Document Type and Number:
WIPO Patent Application WO/2012/069190
Kind Code:
A3
Abstract:
It is desirable to produce live vaccines, which are highly attenuated and which do only contain minimal or no animal-derived components. The production of highly attenuated live viruses can be better achieved when using specifically designed cell lines as producer substrate as opposed to using less defined primary cells. However, live viruses, thus produced comprise undesirable components from the cell lines and cell culture. The present invention relates to methods of production and purification of live enveloped viruses, which are suitable for vaccination.
More Like This:
Inventors:
JORDAN INGO (DE)
BERNHARDT HOLGER (DE)
HARTMANN STEFAN (DE)
BERNHARDT HOLGER (DE)
HARTMANN STEFAN (DE)
Application Number:
PCT/EP2011/005901
Publication Date:
November 15, 2012
Filing Date:
November 23, 2011
Export Citation:
Assignee:
PROBIOGEN AG (DE)
JORDAN INGO (DE)
BERNHARDT HOLGER (DE)
HARTMANN STEFAN (DE)
JORDAN INGO (DE)
BERNHARDT HOLGER (DE)
HARTMANN STEFAN (DE)
International Classes:
C12N7/02
Domestic Patent References:
| WO2001048155A2 | 2001-07-05 |
Other References:
MICHAEL W. WOLFF ET AL: "Purification of cell culture-derived modified vaccinia ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography", BIOTECHNOLOGY AND BIOENGINEERING, vol. 107, no. 2, 1 October 2010 (2010-10-01), pages 312 - 320, XP055018569, ISSN: 0006-3592, DOI: 10.1002/bit.22797
MICHAEL W. WOLFF ET AL: "Capturing of cell culture-derived modified Vaccinia Ankara virus by ion exchange and pseudo-affinity membrane adsorbers", BIOTECHNOLOGY AND BIOENGINEERING, vol. 105, no. 4, 1 March 2010 (2010-03-01), pages 761 - 769, XP055018568, ISSN: 0006-3592, DOI: 10.1002/bit.22595
LARS OPITZ ET AL: "Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles", BIOTECHNOLOGY AND BIOENGINEERING, vol. 103, no. 6, 15 August 2009 (2009-08-15), pages 1144 - 1154, XP055018567, ISSN: 0006-3592, DOI: 10.1002/bit.22345
MICHAEL W. WOLFF ET AL: "Capturing of cell culture-derived modified Vaccinia Ankara virus by ion exchange and pseudo-affinity membrane adsorbers", BIOTECHNOLOGY AND BIOENGINEERING, vol. 105, no. 4, 1 March 2010 (2010-03-01), pages 761 - 769, XP055018568, ISSN: 0006-3592, DOI: 10.1002/bit.22595
LARS OPITZ ET AL: "Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles", BIOTECHNOLOGY AND BIOENGINEERING, vol. 103, no. 6, 15 August 2009 (2009-08-15), pages 1144 - 1154, XP055018567, ISSN: 0006-3592, DOI: 10.1002/bit.22345
Attorney, Agent or Firm:
VOSSIUS, Volker et al. (München, DE)
Download PDF:
Previous Patent: CONDUCTOR TRACK ARRANGEMENT FOR PORTABLE DATA STORAGE MEDIUM
Next Patent: BEARING WITH INTEGRATED SEALS
Next Patent: BEARING WITH INTEGRATED SEALS