Title:
β‑ELEMENE DERIVATIVE CONTAINING N-OH BOND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160011
Kind Code:
A1
Abstract:
Disclosed are a β‑Elemene derivative containing an N-OH bond, a preparation method therefor and a use thereof. The present invention provides a class of β‑Elemene derivatives containing an N-OH bond having the structure shown in formula (I), pharmaceutical compositions containing the compounds of formula (I) and hydrates, as well as isotope derivatives, chiral isomers, variants, different salts, prodrugs, formulations and the like of these compounds. The present invention also provides a preparation method for and a use of the class of β‑Elemene derivatives containing an N-OH bond and the activity of the compounds on proliferation inhibition of various tumor cell strains. The class of β‑Elemene derivatives containing an N-OH bond in the present invention is expected to become an anti-tumor candidate drug for treating lung cancer.
Inventors:
XIE TIAN (CN)
YE XIANGYANG (CN)
GAO YUAN (CN)
BAI RENREN (CN)
LUO XINYU (CN)
CHEN YU (CN)
YE XIANGYANG (CN)
GAO YUAN (CN)
BAI RENREN (CN)
LUO XINYU (CN)
CHEN YU (CN)
Application Number:
PCT/CN2022/130449
Publication Date:
August 31, 2023
Filing Date:
November 08, 2022
Export Citation:
Assignee:
UNIV HANGZHOU NORMAL (CN)
International Classes:
C07D213/73; A61K31/165; A61K31/166; A61K31/277; A61K31/44; A61K31/4406; A61K31/47; A61K31/505; A61P11/00; A61P35/00; C07C259/10; C07D213/54; C07D213/78; C07D215/48; C07D239/28; C07D239/42; C07D317/68
Domestic Patent References:
| WO2006016912A2 | 2006-02-16 |
Foreign References:
| CN107216283A | 2017-09-29 | |||
| CN111718352A | 2020-09-29 | |||
| CN101239915A | 2008-08-13 | |||
| CN1844105A | 2006-10-11 | |||
| CN114573504A | 2022-06-03 |
Other References:
LIU GUIFENG, KONG ZHENWU, SHEN YUMEI: "Synthesis, characterization, and in vitro antiproliferative activity of novel β-elemene monosubstituted derivatives", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 22, no. 7, 1 July 2013 (2013-07-01), US , pages 3536 - 3540, XP093085421, ISSN: 1054-2523, DOI: 10.1007/s00044-013-0615-3
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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