Title:
DERIVATIVE OF HOMOSERINE LACTONE, AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/121633
Kind Code:
A1
Abstract:
Disclosed are a derivative of homoserine lactone shown in formula I, and a preparation method and use thereof. The compound has a function of sensing and regulating a bacterial colony, and can be used for prevention and/or treatment of related diseases caused by bacterial infection.
Inventors:
LI SONG (CN)
XIAO JUNHAI (CN)
ZHAO MINGMING (CN)
ZHONG WU (CN)
WANG LILI (CN)
ZHENG ZHIBING (CN)
XIE YUNDE (CN)
LI XINGZHOU (CN)
ZHAO GUOMING (CN)
ZHOU XINBO (CN)
WANG XIAOKUI (CN)
CHEN WEI (CN)
XIAO JUNHAI (CN)
ZHAO MINGMING (CN)
ZHONG WU (CN)
WANG LILI (CN)
ZHENG ZHIBING (CN)
XIE YUNDE (CN)
LI XINGZHOU (CN)
ZHAO GUOMING (CN)
ZHOU XINBO (CN)
WANG XIAOKUI (CN)
CHEN WEI (CN)
Application Number:
PCT/CN2013/088932
Publication Date:
August 14, 2014
Filing Date:
December 10, 2013
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
International Classes:
A61K31/635; C07D307/33; A61P31/04
Domestic Patent References:
| WO2008116029A1 | 2008-09-25 |
Foreign References:
| KR20080046434A | 2008-05-27 |
Other References:
YU , YINGYING: "Design, Synthesis and Biological Evaluation of Antagonists of Bacterial Quorum Sensing", MASTER'S THESIS OF JILIN UNIVERSITY, 15 July 2013 (2013-07-15), XP028252900
KIM, C. ET AL.: "Development of inhibitors against TraR quorum-sensing system in Agrobacterium tumefaciens by molecular modeling of the ligand-receptor interaction", MOLECULES AND CELLS, vol. 28, no. 5, 2009, pages 447 - 453, XP055271425
CASTANG, S. ET AL.: "N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 20, 2004, pages 5145 - 5149, XP029246125
KIM, C. ET AL.: "Development of inhibitors against TraR quorum-sensing system in Agrobacterium tumefaciens by molecular modeling of the ligand-receptor interaction", MOLECULES AND CELLS, vol. 28, no. 5, 2009, pages 447 - 453, XP055271425
CASTANG, S. ET AL.: "N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 20, 2004, pages 5145 - 5149, XP029246125
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
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