DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF gamma -HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Title:

DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF gamma -HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Document Type and Number:

WIPO Patent Application WO2002042250

Kind Code:

B1

Abstract:

The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydrxoybutanoic acid and of its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues, pharmaceutical compositions containing them and their pharmaceutical uses. Said novel derivatives are capable of binding with gamma -hydroxybutyrate (GHB)-specific receptors and hence capable of exhibiting agonist or antagonist properties, in particular for treating sleep disorders, anxiety and general diseases of the central nervous system. The invention also concerns compounds of general formula (I) wherein the substituents are as defined in the description.

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Inventors:

BOURGUIGNON JEAN-JACQUES (FR)
MAITRE MICHEL (FR)
KLOTZ EVELYNE (FR)
SCHMITT MARTINE (FR)
GOBAILLE SERGE (FR)
MACHER JEAN-PAUL (FR)

Application Number:

PCT/FR2001/003615

Publication Date:

July 18, 2002

Filing Date:

November 16, 2001

Export Citation:

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Assignee:

UNIV LOUIS PASTEUR ETABLISSEME (FR)
BOURGUIGNON JEAN-JACQUES (FR)
MAITRE MICHEL (FR)
KLOTZ EVELYNE (FR)
SCHMITT MARTINE (FR)
GOBAILLE SERGE (FR)
MACHER JEAN-PAUL (FR)

International Classes:

A61P25/00; A61P25/08; A61P25/18; A61P25/24; C07C59/48; C07C59/56; C07C59/64; C07C229/42; C07C233/54; C07C259/06; C07D207/34; C07D207/48; C07D209/08; C07D209/18; C07D209/34; C07D209/42; C07D209/86; C07D213/55; C07D215/227; C07D215/233; C07D223/22; C07D241/42; C07D307/33; C07D307/58; C07D307/79; C07D307/91; C07D319/06; C07D319/18; C07D327/08; C07D333/24; C07D333/60; C07D333/76; C07D405/04; C07D471/04; C07D487/04; C07D215/22; (IPC1-7): C07C59/48; C07C59/56; C07C59/64; C07C235/34; C07D207/48; C07D213/55; C07D333/24; C07D207/34; C07D307/79; C07D311/20; C07D209/08; C07D209/42; C07D333/60; C07D215/22; C07D471/04; C07D209/34; C07D333/76; C07D487/04; C07D307/91; C07D209/86; C07D327/06; C07D243/38; C07D311/82; A61K31/191; A61K31/38; A61K31/395; A61K31/44; A61K31/47; A61P25/08; A61P25/18; A61P25/24

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