Title:
DERIVATIVES OF 5-AMINO-8-CHLORINE-DIBENZO[b,e][1,4]-DIAZEPINE AND A PHARMACEUTICAL PREPARATION FOR TREATMENT OF EPILEPSY AND EPILEPTIC STATUS BASED THEREON
Document Type and Number:
WIPO Patent Application WO/1991/010661
Kind Code:
A1
Abstract:
Derivatives of 5-amino-8-chlorine-dibenzo[b,e][1,4]-diazepine of general formula (I) where R = H or -COR', where R' = CH�3?, C�2?H�5?, C�3?H�7?, C�4?H�9?, C�5?H�11? and CH(CH�3?)�2?. The claimed compounds have an anticonvulsive activity. A pharmaceutical preparation for treatment of epilepsy and epileptic status comprises, as an active substance, the most effective claimed compound: 5-acetylamino-8-chlorine-11-(1-methylpiperazine-4-yl)-dibenzo[b,e][1,4]-diazepine.
Inventors:
CHERNOV GRIGORY SEMENOVICH (SU)
KHLIENKO ZHANNA NIKOLAEVNA (SU)
MEKHOVA GALINA MIKHAILOVNA (SU)
SUSEKOVA TATYANA VIKTOROVNA (SU)
KOLLA VIKTOR EDUARDOVICH (SU)
SULDIN ALEXANDR VLADIMIROVICH (SU)
SHELENKOVA SVETLANA ALEXANDROV (SU)
TREGUBOV ALEXANDR LEONIDOVICH (SU)
PILIPCHUK TATYANA VALERIEVNA (SU)
NIKUSHKIN EVGENY VASILIEVICH (SU)
KRUPINA NATALYA ALEXANDROVNA (SU)
KUCHERYANU VALERY GRIGORIEVICH (SU)
KHLIENKO ZHANNA NIKOLAEVNA (SU)
MEKHOVA GALINA MIKHAILOVNA (SU)
SUSEKOVA TATYANA VIKTOROVNA (SU)
KOLLA VIKTOR EDUARDOVICH (SU)
SULDIN ALEXANDR VLADIMIROVICH (SU)
SHELENKOVA SVETLANA ALEXANDROV (SU)
TREGUBOV ALEXANDR LEONIDOVICH (SU)
PILIPCHUK TATYANA VALERIEVNA (SU)
NIKUSHKIN EVGENY VASILIEVICH (SU)
KRUPINA NATALYA ALEXANDROVNA (SU)
KUCHERYANU VALERY GRIGORIEVICH (SU)
Application Number:
PCT/SU1991/000001
Publication Date:
July 25, 1991
Filing Date:
January 10, 1991
Export Citation:
Assignee:
NOVOKUZNETSKY NI KHIM FARM (SU)
International Classes:
C07D243/38; (IPC1-7): C07D403/04
Foreign References:
| CH601288A5 | 1978-07-14 | |||
| US4096261A | 1978-06-20 | |||
| GB1554275A | 1979-10-17 | |||
| US4208207A | 1980-06-17 | |||
| SU920055A1 | 1982-04-15 | |||
| US4388237A | 1983-06-14 |
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