DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES

WIPO Patent Application WO/1992/019598

A1

New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R1 = H, CH3, Br; R2 = H, CH3; R3 = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9-aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-aminogroup, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals , the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations.

BUROV YURI VALENTINOVICH (RU)
GONCHARENKO SERGEI BORISOVICH (RU)
ROBAKIDZE TATIANA NIKOLAEVNA (RU)
PORTNOV YURI NIKOLAEVICH (RU)
KADYSHEVA LYUBOV VLADISLAVOVNA (RU)
PENKE ILMAR CHARIEVICH (LV)
PEGANOV EDUARD MAKSIMOVICH (RU)
SUCHANOVA SVETLANA ALEKSEEVNA (RU)
TANANOBA GALINA VASILIEVNA (RU)
VORONIN ANATOLII EVGENIEVICH (RU)

PCT/RU1992/000096

November 12, 1992

May 06, 1992

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PASNOSTI BIOLOG ACTIVNYCH VESH (RU)
LATVIISKOE PROIZV BIOFARM OB (LV)

A61K31/473; A61K31/4741; A61P25/18; C07D219/10; C07D219/12; (IPC1-7): A61K31/435; C07D219/10; C07D219/12

EP0268871A1	1988-06-01
EP0282959A2	1988-09-21
US4695573A	1987-09-22

MASHKOVSKY M.D., "Lekarstvennye Sredstva", Tom 1, 1986, Meditsina (Moscow), page 117.
See also references of EP 0633251A4

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