Title:
DERIVATIVES OF ANTIBODY AGAINST GANGLIOSIDE GM2
Document Type and Number:
WIPO Patent Application WO/2001/023431
Kind Code:
A1
Abstract:
Derivatives of an antibody against ganglioside GM2 (hereinafter referred to as GM2); fragments of the antibody against GM2; and diagnostics and remedies for cancer with the use of the above derivatives and antibody fragments.
Inventors:
HANAI NOBUO (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
Application Number:
PCT/JP2000/006775
Publication Date:
April 05, 2001
Filing Date:
September 29, 2000
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
HANAI NOBUO (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
HANAI NOBUO (JP)
NAKAMURA KAZUYASU (JP)
NIWA RINPEI (JP)
International Classes:
A61P35/00; C07K16/18; C12N15/13; C12N15/26; C12P21/08; A61K38/00; (IPC1-7): C07K16/18; A61K39/395; A61P35/00; C07K14/55; C07K19/00; C12N5/10; C12N15/13; C12N15/26; C12N15/62; C12P21/08; G01N33/566; G01N33/577
Foreign References:
| EP0882794A2 | 1998-12-09 | |||
| EP0598998A2 | 1994-06-01 | |||
| JPH041138A | 1992-01-06 |
Other References:
GILLIES S.D. ET AL.: "Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells", PROC. NATL. ACAD. SCI. USA, vol. 89, no. 4, 1992, pages 1428 - 1432, XP002934391
SABZEVARI H. ET AL.: "A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice", PROC. NATL. ACAD. SCI. USA, vol. 91, no. 20, 1994, pages 9626 - 9630, XP002934392
HOLGER N. LODE ET AL.: "Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy", BLOOD, vol. 91, no. 5, 1998, pages 1706 - 1715, XP002934393
SABZEVARI H. ET AL.: "A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice", PROC. NATL. ACAD. SCI. USA, vol. 91, no. 20, 1994, pages 9626 - 9630, XP002934392
HOLGER N. LODE ET AL.: "Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy", BLOOD, vol. 91, no. 5, 1998, pages 1706 - 1715, XP002934393
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