Title:
DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE
Document Type and Number:
WIPO Patent Application WO2004056365
Kind Code:
A3
Abstract:
A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.
Inventors:
ALTMANN EVA (CH)
BEERLI RENE (CH)
GERSPACHER MARC (CH)
RENAUD JOHANNE (CH)
WEILER SVEN (DE)
WIDLER LEO (CH)
BEERLI RENE (CH)
GERSPACHER MARC (CH)
RENAUD JOHANNE (CH)
WEILER SVEN (DE)
WIDLER LEO (CH)
Application Number:
PCT/EP2003/014741
Publication Date:
August 19, 2004
Filing Date:
December 22, 2003
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
ALTMANN EVA (CH)
BEERLI RENE (CH)
GERSPACHER MARC (CH)
RENAUD JOHANNE (CH)
WEILER SVEN (DE)
WIDLER LEO (CH)
NOVARTIS PHARMA GMBH (AT)
ALTMANN EVA (CH)
BEERLI RENE (CH)
GERSPACHER MARC (CH)
RENAUD JOHANNE (CH)
WEILER SVEN (DE)
WIDLER LEO (CH)
International Classes:
A61P5/18; C07C17/12; C07C45/30; C07C205/37; C07C205/44; C07C205/45; C07C225/22; C07C229/18; C07C255/24; C07C255/25; C07C317/18; C07C317/32; C07C323/25; C07D213/64; C07D239/82; C07D239/93; C07D317/58; C07D401/06; C07D401/12; C07D403/06; C07D403/10; C07D405/06; C07D409/06; C07D413/06; C07D417/06; (IPC1-7): A61K31/498; C07D403/06; C07D239/82; C07D403/10; C07D409/06; C07D405/06; C07D417/06; C07D401/06; C07D413/06; C07D401/12; C07D239/78; C07C49/84; A61P5/18
Domestic Patent References:
| WO2002024683A1 | 2002-03-28 | |||
| WO2002102782A2 | 2002-12-27 |
Foreign References:
| US4387223A | 1983-06-07 | |||
| CH612186A5 | 1979-07-13 | |||
| US3812257A | 1974-05-21 | |||
| GB1353789A | 1974-05-22 | |||
| US5773663A | 1998-06-30 | |||
| US5856503A | 1999-01-05 | |||
| US3925548A | 1975-12-09 | |||
| US6211244B1 | 2001-04-03 |
Other References:
RUSSELL, R. K. ET AL: "Synthesis and renal vasodilator activity of substituted [4-alkyl(aryl)-2-oxoquinazolin-1-yl]alkanoic acids", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 3, 1992, pages 277 - 284, XP002935850
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280288, retrieved from STN accession no. 1306 Database accession no. 1980:121782
MASAI, NARUHITO ET AL: "Carbon-13 nuclear magnetic resonance studies of anti-inflammatory 2(1H)-quinazolinones", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 25, no. 11, 1977, pages 3018 - 3022, XP009000437
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280289, retrieved from STN accession no. 1406 Database accession no. 1982:503745
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280290, retrieved from STN accession no. 1142 Database accession no. 1994:244939
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280291, retrieved from STN accession no. 1277 Database accession no. 1981:461773
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002280292, Database accession no. 6810088
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280288, retrieved from STN accession no. 1306 Database accession no. 1980:121782
MASAI, NARUHITO ET AL: "Carbon-13 nuclear magnetic resonance studies of anti-inflammatory 2(1H)-quinazolinones", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 25, no. 11, 1977, pages 3018 - 3022, XP009000437
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280289, retrieved from STN accession no. 1406 Database accession no. 1982:503745
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280290, retrieved from STN accession no. 1142 Database accession no. 1994:244939
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002280291, retrieved from STN accession no. 1277 Database accession no. 1981:461773
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002280292, Database accession no. 6810088
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