Title:
DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/192527
Kind Code:
A1
Abstract:
Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided.
Inventors:
HAN NIANHE (CN)
AN DEQIANG (CN)
ZHU PENG (CN)
HOU CHENGYU (CN)
YANG HANG (CN)
JIAN LI (CN)
YANG CHUN (CN)
AN DEQIANG (CN)
ZHU PENG (CN)
HOU CHENGYU (CN)
YANG HANG (CN)
JIAN LI (CN)
YANG CHUN (CN)
Application Number:
PCT/CN2016/082286
Publication Date:
December 08, 2016
Filing Date:
May 17, 2016
Export Citation:
Assignee:
NEWBIO THERAPEUTICS INC (CN)
International Classes:
C07K7/06; A61K38/08; A61K39/395; A61K39/44; A61K47/48; A61P35/00
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Other References:
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DORONINA, S.O. ET AL.: "Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery: Effects of Linker Technology on Efficacy and Toxicity.", BIOCONJUGATE CHEM., vol. 17, no. 1, 22 December 2005 (2005-12-22), pages 114 - 124, XP055009264
BIOCONJUGATE CHEM., vol. 13, 2002, pages 855 - 869
"Remington's Pharmaceutical Sciences", 1991, MACK PUB. CO.
SCIENCE, vol. 189, 1975, pages 1002 - 1005
BIOCHEMISTRY, vol. 47, 2008, pages 11818 - 11829
BIOCONJUGATE CHEM., vol. 21, 2010, pages 5 - 13
TETRAHEDRON, vol. 61, 2005, pages 11132 - 11140
J. CHEM. SOC., vol. 432, 1942
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (Shanghai 3, CN)
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