Title:
DERIVATIVES OF GLYCERO-MANNO-HEPTOSE ADP FOR USE IN MODULATING IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO/2020/216327
Kind Code:
A1
Abstract:
The disclosure provides compounds, compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are as defined herein.
Inventors:
XU TIAN (CN)
XU CONG (CN)
LIU DANYANG (CN)
FAN JIEQING (CN)
PAN YANFANG (CN)
XU CONG (CN)
LIU DANYANG (CN)
FAN JIEQING (CN)
PAN YANFANG (CN)
Application Number:
PCT/CN2020/086691
Publication Date:
October 29, 2020
Filing Date:
April 24, 2020
Export Citation:
Assignee:
SHANGHAI YAO YUAN BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/708; A61K31/7068; A61K31/7072; A61K31/7076; A61P25/00; A61P37/04
Domestic Patent References:
| WO2019080898A1 | 2019-05-02 |
Foreign References:
| US20100016250A1 | 2010-01-21 | |||
| EP1669365A1 | 2006-06-14 |
Other References:
MICHAEL SCHNEIDER, KUMAR VIVEK, NORDSTRØM LARS ULRIK, FENG LEI, TAKEUCHI HIDEYUKI, HAO HUILIN, LUCA VINCENT C, GARCIA K CHRISTOPHE: "Inhibition of Delta-induced Notch signaling using fucose analogs", NATURE CHEMICAL BIOLOGY, vol. 14, 27 November 2017 (2017-11-27), pages 65 - 71, XP055746555, ISSN: 1552-4450, DOI: 10.1038/nchembio.2520
NEIL D WARNOCK; WILSON LEONIE; PATTEN CHERYL; FLEMING COLIN; MAULE AARON; DALZELL JOHNATHAN; MACKEY DAVID: "ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1，7-bisphosphate of gram-negative bacteria", PLOS PATHOGENS, vol. 13, no. 2, e1006237, 27 February 2017 (2017-02-27), pages 1 - 28, XP055467909, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1006237
NEIL D WARNOCK; WILSON LEONIE; PATTEN CHERYL; FLEMING COLIN; MAULE AARON; DALZELL JOHNATHAN; MACKEY DAVID: "ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1，7-bisphosphate of gram-negative bacteria", PLOS PATHOGENS, vol. 13, no. 2, e1006237, 27 February 2017 (2017-02-27), pages 1 - 28, XP055467909, ISSN: 1553-7366, DOI: 10.1371/journal.ppat.1006237
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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