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Title:
DERIVATIVES OF MORPHINE-6-GLUCURONIDE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO/2010/067010
Kind Code:
A3
Abstract:
The invention relates to derivatives of morphine-6-glucuronide having formula (I) wherein R1 is a 5-membered heteroaromatic group optionally substituted by one or more substituents selected from among halogen atoms and (C1-C4)alkyl, halogen, hydroxyl, halo(C1-C4)alkyl, halo(C1-C4)alkyloxy, (C1-C4)alkyloxy, aryl(C1-C4)alkyl and aryl groups, said aryl group being optionally substituted by one or more groups selected from among (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxyl and (C1-C4)alkyloxy groups, in the form of a base or acid addition salt, as well as in hydrate or solvate form. The invention also relates to the preparation method thereof and to the use of same in therapeutics.

Inventors:
DLUBALA, Alain (Département Brevets17, avenue de France Paris, F-75013, FR)
RIPOCHE, Isabelle (Ecole Nationale Supérieure de Clermont-Ferrand, Campus CezeauxB.P. 187, Aubière Cedex, F-63174, FR)
TRECANT, Claire (16 rue de Copenhague, Strasbourg, Strasbourg, F-67000, FR)
Application Number:
FR2009/052448
Publication Date:
June 30, 2011
Filing Date:
December 08, 2009
Export Citation:
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Assignee:
SANOFI (174 avenue de France, Paris, Paris, F-75013, FR)
DLUBALA, Alain (Département Brevets17, avenue de France Paris, F-75013, FR)
RIPOCHE, Isabelle (Ecole Nationale Supérieure de Clermont-Ferrand, Campus CezeauxB.P. 187, Aubière Cedex, F-63174, FR)
TRECANT, Claire (16 rue de Copenhague, Strasbourg, Strasbourg, F-67000, FR)
International Classes:
C07H15/24; A61K31/485; A61K31/70; A61P25/04; A61P29/00; C07H7/06; C07H17/00; C07H17/04
Domestic Patent References:
WO1998046618A11998-10-22
Foreign References:
FR2864082A12005-06-24
Other References:
CHENG GANG ET AL: "syn additions to 4alpha-epoxypyranosides: synthesis of L-idopyranosides.", ORGANIC LETTERS 8 NOV 2007, vol. 9, no. 23, 8 November 2007 (2007-11-08), pages 4849 - 4852, XP002544745, ISSN: 1523-7060
MCMILLAN K G ET AL: "Synthesis, structure and reactivity of 5-pyranosyl-1,3,4-oxathiazol-2-on", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 341, no. 1, 16 January 2006 (2006-01-16), pages 41 - 48, XP025010249, ISSN: 0008-6215, [retrieved on 20060116]
DANISHEFSKY S J ET AL: "A STEREOSELECTIVE TOTALLY SYNTHETIC ROUTE TO METHYL ALPHA-PERACETYLHIKOSAMINIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 6, 1989, pages 2193 - 2204, XP002544746, ISSN: 0002-7863
Attorney, Agent or Firm:
PIGASSE, Caroline (Département Brevets17, avenue de France Paris, F-75013, FR)
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