Title:
DERIVATIVES OF MORPHINE-6-GLUCURONIDE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO/2010/067010
Kind Code:
A3
Abstract:
The invention relates to derivatives of morphine-6-glucuronide having formula (I) wherein R1 is a 5-membered heteroaromatic group optionally substituted by one or more substituents selected from among halogen atoms and (C1-C4)alkyl, halogen, hydroxyl, halo(C1-C4)alkyl, halo(C1-C4)alkyloxy, (C1-C4)alkyloxy, aryl(C1-C4)alkyl and aryl groups, said aryl group being optionally substituted by one or more groups selected from among (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxyl and (C1-C4)alkyloxy groups, in the form of a base or acid addition salt, as well as in hydrate or solvate form. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
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Inventors:
DLUBALA ALAIN (FR)
RIPOCHE ISABELLE (FR)
TRECANT CLAIRE (FR)
RIPOCHE ISABELLE (FR)
TRECANT CLAIRE (FR)
Application Number:
PCT/FR2009/052448
Publication Date:
June 30, 2011
Filing Date:
December 08, 2009
Export Citation:
Assignee:
SANOFI SA (FR)
DLUBALA ALAIN (FR)
RIPOCHE ISABELLE (FR)
TRECANT CLAIRE (FR)
DLUBALA ALAIN (FR)
RIPOCHE ISABELLE (FR)
TRECANT CLAIRE (FR)
International Classes:
C07H15/24; A61K31/485; A61K31/70; A61P25/04; A61P29/00; C07H7/06; C07H17/00; C07H17/04
Domestic Patent References:
| WO1998046618A1 | 1998-10-22 |
Foreign References:
| FR2864082A1 | 2005-06-24 |
Other References:
CHENG GANG ET AL: "syn additions to 4alpha-epoxypyranosides: synthesis of L-idopyranosides.", ORGANIC LETTERS 8 NOV 2007, vol. 9, no. 23, 8 November 2007 (2007-11-08), pages 4849 - 4852, XP002544745, ISSN: 1523-7060
MCMILLAN K G ET AL: "Synthesis, structure and reactivity of 5-pyranosyl-1,3,4-oxathiazol-2-on", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 341, no. 1, 16 January 2006 (2006-01-16), pages 41 - 48, XP025010249, ISSN: 0008-6215, [retrieved on 20060116]
DANISHEFSKY S J ET AL: "A STEREOSELECTIVE TOTALLY SYNTHETIC ROUTE TO METHYL ALPHA-PERACETYLHIKOSAMINIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 6, 1989, pages 2193 - 2204, XP002544746, ISSN: 0002-7863
MCMILLAN K G ET AL: "Synthesis, structure and reactivity of 5-pyranosyl-1,3,4-oxathiazol-2-on", CARBOHYDRATE RESEARCH, ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, NL, vol. 341, no. 1, 16 January 2006 (2006-01-16), pages 41 - 48, XP025010249, ISSN: 0008-6215, [retrieved on 20060116]
DANISHEFSKY S J ET AL: "A STEREOSELECTIVE TOTALLY SYNTHETIC ROUTE TO METHYL ALPHA-PERACETYLHIKOSAMINIDE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 6, 1989, pages 2193 - 2204, XP002544746, ISSN: 0002-7863
Attorney, Agent or Firm:
PIGASSE, Caroline (Département Brevets17, avenue de France Paris, FR)
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